N-[3-(trifluoromethyl)phenyl]piperidin-4-amine, hydrochloride salt

Base Information

• Chemical Name: N-[3-(trifluoromethyl)phenyl]piperidin-4-amine, hydrochloride salt
• CAS No.: 1247029-73-7
• Molecular Formula: C₁₂H₁₅F₃N₂*ClH
• Molecular Weight: 280.721
• Mol file: 1247029-73-7.mol

Synonyms:N-[3-(trifluoromethyl)phenyl]piperidin-4-amine, hydrochloride salt

Chemical Property of N-[3-(trifluoromethyl)phenyl]piperidin-4-amine, hydrochloride salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[3-(trifluoromethyl)phenyl]piperidin-4-amine, hydrochloride salt

There total 4 articles about N-[3-(trifluoromethyl)phenyl]piperidin-4-amine, hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyl 4-((3-(trifluoromethyl)phenyl)amino)piperidine-1-carboxylate (477864-09-8) → N-[3-(trifluoromethyl)phenyl]piperidin-4-amine, hydrochloride salt (1247029-73-7)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; Inert atmosphere;

DOI:10.1039/d1md00023c

Reference yield:

3-trifluoromethylaniline (98-16-8) + 1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) → N-[3-(trifluoromethyl)phenyl]piperidin-4-amine, hydrochloride salt (1247029-73-7)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 16 h / 90 °C

2: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → N-[3-(trifluoromethyl)phenyl]piperidin-4-amine, hydrochloride salt (1247029-73-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 2 h / 0 - 20 °C

2: hydrogenchloride / ethyl acetate / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tris(acetoxy)borohydride; acetic acid; In ethyl acetate; 1,2-dichloro-ethane;

DOI:10.1039/d1md00023c

upstream raw materials:

3-trifluoromethylaniline

1-(tert-butoxycarbonyl)-4-aminopiperidine

tert-butyl 4-((3-(trifluoromethyl)phenyl)amino)piperidine-1-carboxylate

N-tert-butyloxycarbonylpiperidin-4-one

Refernces

• 1、 -. "Spiroalkene carboxamide derivatives and their use as chemokine receptor modulators". . . Retrieved 2012/10/18.