Indolizino[1,2-b]quinoline-7-acetic acid,a-ethyl-9,11-dihydro-a-hydroxy-8-(hydroxymethyl)-9-oxo-, monosodiumsalt, (aS)-

Base Information

• Chemical Name: Indolizino[1,2-b]quinoline-7-acetic acid,a-ethyl-9,11-dihydro-a-hydroxy-8-(hydroxymethyl)-9-oxo-, monosodiumsalt, (aS)-
• CAS No.: 25387-67-1
• Molecular Formula: C20H18 N2 O5 . Na
• Molecular Weight: 370.36
• Hs Code.: 2942000000
• Mol file: 25387-67-1.mol

Synonyms:Sodium camptothecin;Indolizino[1,2-b]quinoline-7-acetic acid,a-ethyl-9,11-dihydro-a-hydroxy-8-(hydroxymethyl)-9-oxo-, monosodiumsalt, (aS)-;25387-67-1;NCGC00014050;CCG-37438;NCI100880;AKOS040757842;NCGC00014050-02;NCGC00097159-01

Chemical Property of Indolizino[1,2-b]quinoline-7-acetic acid,a-ethyl-9,11-dihydro-a-hydroxy-8-(hydroxymethyl)-9-oxo-, monosodiumsalt, (aS)-

Chemical Property:

• Vapor Pressure: 1.96E-25mmHg at 25°C
• Boiling Point: 777.3°C at 760 mmHg
• Flash Point: 423.9°C
• PSA: 115.48000
• LogP: 0.26500
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 389.11134096
• Heavy Atom Count: 28
• Complexity: 730

Purity/Quality:

99% ^*data from raw suppliers

sodium camptothecin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C1=C(C(=O)N2CC3=CC4=CC=CC=C4N=C3C2=C1)CO)(C(=O)O)O.[Na]
• Isomeric SMILES: CC[C@](C1=C(C(=O)N2CC3=CC4=CC=CC=C4N=C3C2=C1)CO)(C(=O)O)O.[Na]
• Uses: Sodium Camptothecin is the salt form of Camptothecin.

Technology Process of Indolizino[1,2-b]quinoline-7-acetic acid,a-ethyl-9,11-dihydro-a-hydroxy-8-(hydroxymethyl)-9-oxo-, monosodiumsalt, (aS)-

There total 1 articles about Indolizino[1,2-b]quinoline-7-acetic acid,a-ethyl-9,11-dihydro-a-hydroxy-8-(hydroxymethyl)-9-oxo-, monosodiumsalt, (aS)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

camptothecin (7689-03-4,91926-09-9) → 20(S)-camptothecin sodium salt (25387-67-1)

Guidance literature:

With sodium hydroxide; water; at 50 ℃; for 1h;

upstream raw materials:

camptothecin

Refernces

• 1、 -. "Loading of a camptothecin drug into colloidal nanoparticles". Page/Page column 13. . Retrieved 2008/06/13.