Cyanophos

Base Information

• Chemical Name: Cyanophos
• CAS No.: 2636-26-2
• Deprecated CAS: 12692-90-9,54578-39-1
• Molecular Formula: C9H10 N O3 P S
• Molecular Weight: 243.223
• Hs Code.: 29269090
• European Community (EC) Number: 220-130-3
• UN Number: 3018
• UNII: 2AB0Z99OXP
• DSSTox Substance ID: DTXSID0041806
• Nikkaji Number: J3.394D
• Wikipedia: Cyanophos
• Wikidata: Q1147014
• NCI Thesaurus Code: C163644
• Metabolomics Workbench ID: 55939
• ChEMBL ID: CHEMBL2271089
• Mol file: 2636-26-2.mol

Synonyms:cyanophos;Cyanox

Chemical Property of Cyanophos

Chemical Property:

• Vapor Pressure: 0.000282mmHg at 25°C
• Melting Point: 14-15oC
• Refractive Index: nD32.5 1.5404
• Boiling Point: 322.3 °C at 760 mmHg
• Flash Point: 148.7 °C
• PSA: 93.38000
• Density: 1.3 g/cm³
• LogP: 3.10498
• Storage Temp.: 0-6°C
• Water Solubility.: 46 mg l-1 (30 °C)
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 243.01190135
• Heavy Atom Count: 15
• Complexity: 285
• Transport DOT Label: Poison

Purity/Quality:

99.90% ^*data from raw suppliers

Cyanophos ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Poison. A cholinesterase inhibitor.
• Hazard Codes: Xn,N
• Statements: 21/22-50/53
• Safety Statements: 36/37-60-61

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Pesticides -> Organophosphate Insecticides
• Canonical SMILES: COP(=S)(OC)OC1=CC=C(C=C1)C#N
• Description: Cyanophos is an amber liquid, decomposes at 119–120 ?C, vp 105 mPa (20 ?C). Solubility in water is 46 mg/L (30 ?C). It is soluble in most organic solvents. Log Kow = 2.65. Cyanophos is effective in controlling a variety of insect pests including rice stem borers. Major formulation types are dustable powder, emulsifiable concentrate, wettable powder, and ultra low volume liquid.
• Uses: Cyanophos is a cholinesterase inhibitor used as an insecticide and avicide. Insecticide. Cyanophos is used to control a number of chewing and sucking pests in cotton, fruit and vegetables and public health pests.

Technology Process of Cyanophos

There total 4 articles about Cyanophos which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

potassium p-cyanophenoxide (5633-96-5) + dimethyl chlorothiophosphate (2524-03-0) → cyanophos (2636-26-2)

Guidance literature:

Reference yield: 43.0%

dimethyl thiophosphite (5930-72-3) + 4-cyanophenol (767-00-0) → cyanophos (2636-26-2)

Guidance literature:

With tert.-butylhydroperoxide; lithium iodide; In water; acetonitrile; at 20 ℃; for 0.25h;

DOI:10.1002/ejoc.201901362

Reference yield:

→ cyanophos (2636-26-2)

Guidance literature:

O,O-Dimethyl-thiophosphorsaeurechlorid, 4-Hydroxy-benzonitril, K2CO3;

upstream raw materials:

potassium p-cyanophenoxide

dimethyl chlorothiophosphate

MEP

4-cyanophenol

Downstream raw materials:

C₉H₁₁O₅PS

p-cyanophenyl dimethyl phosphate

O-(4-carbamoylphenyl) O,O-dimethyl thiophosphate

4-cyanophenol

Refernces

• 1、 Anitha, Thippani,Ashalu, Kashamalla Chinna,Sandeep, Mummadi,Mohd, Aabid,Wencel-Delord, Joanna,Colobert, Francoise,Reddy, Kallu Rajender. "LiI/TBHP Mediated Oxidative Cross-Coupling of P(O)–H Compounds with Phenols and Various Nucleophiles: Direct Access to the Synthesis of Organophosphates". . p. 7463 - 7474. Retrieved 2019/12/03.
• 2、 Ponomarchuk, M. P.,Kasukhin, L. F.,Budilova, I. Yu.,Gololobov, Yu. G.. "STERIC EFFECT IN REACTIONS OF PHENYL ESTERS OF PHOSPHORUS ACIDS". . p. 1561 - 1568. Retrieved 2007/10/02.