Thiophosphonic acid dimethyl ester

Base Information

• Chemical Name: Thiophosphonic acid dimethyl ester
• CAS No.: 5930-72-3
• Molecular Formula: C2H7 O2 P S
• Molecular Weight: 126.116
• Nikkaji Number: J223.896I
• Mol file: 5930-72-3.mol

Synonyms:Thiophosphonic acid dimethyl ester

Chemical Property of Thiophosphonic acid dimethyl ester

Chemical Property:

• Vapor Pressure: 26.677mmHg at 25°C
• Boiling Point: 59 °C16 mm Hg(lit.)
• Flash Point: 111 °F
• PSA: 74.02000
• Density: 1.185 g/mL at 25 °C(lit.)
• LogP: 1.43590
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 125.99043763
• Heavy Atom Count: 6
• Complexity: 49.5

Purity/Quality:

98%,99%, ^*data from raw suppliers

DIMETHYL THIOPHOSPHONATE 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COP(=S)OC
• Uses: Dimethyl Thiophosphonate is a reagent used in the synthesis of new phosphoric acid ester insecticides. It is also a reagent for the preparation of organophosphorus insecticides.

Technology Process of Thiophosphonic acid dimethyl ester

There total 10 articles about Thiophosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

Dimethyl phosphite (868-85-9) → dimethyl thiophosphite (5930-72-3)

Guidance literature:

With Lawessons reagent; In benzene; for 0.75h; Heating; or 30 d, r.t.;

Reference yield: 68.4%

phosphorous acid trimethyl ester (121-45-9) → dimethyl thiophosphite (5930-72-3)

Guidance literature:

With hydrogen sulfide; N,N-diethylaniline; at 53 - 54 ℃; for 24h; under 9120 - 9880 Torr;

DOI:10.1080/10426500307878

Reference yield: 66.0%

dimethyl S-methyl phosphorodithioate (2953-29-9) + isopropyl alcohol (67-63-0,8013-70-5) → dimethyl thiophosphite (5930-72-3) + thiophosphoric acid O-isopropyl ester O',O''-dimethyl ester (75511-31-8) + thiophosphoric acid O-isopropyl ester O',S-dimethyl ester (75511-33-0) + O,O-dimethyl phosphorodithioic acid (756-80-9)

Guidance literature:

In acetonitrile; Product distribution; Mechanism; Quantum yield; Irradiation; var. of solvent, conc., competition with MeOH, further with triplet sensitizers;

DOI:10.1039/c39800000370

upstream raw materials:

methyl phosphite

dimethyl chlorophosphite

Dimethyl phosphite

dimethyl S-methyl phosphorodithioate

Downstream raw materials:

dimethyl (2-cyanoethyl)phosphonate

(1-Trimethylsilanyloxy-vinyl)-phosphonothioic acid O,O-dimethyl ester

parathion-methyl

cyanophos

Refernces

• 1、 -. "Thiophosphonate inhibitors of phosphatase enzymes and metallophosphatases". Page/Page column 12. . Retrieved 2010/02/11.
• 2、 Hudson, Harry R.,Jaszay, Zsuzsa M.,Pianka, Max. "The preparation and properties of some α-acyloxy- and α-carbamoyloxy-phosphonothionates". . p. 1571 - 1582. Retrieved 2007/10/03.