Phencyclidine hydrochloride

Base Information

• Chemical Name: Phencyclidine hydrochloride
• CAS No.: 956-90-1
• Molecular Formula: C17H25N•ClH
• Molecular Weight: 279.853
• Hs Code.: 2933330000
• European Community (EC) Number: 624-818-8
• NSC Number: 40902
• UNII: V1JZQ7GDTX
• DSSTox Substance ID: DTXSID70893724
• Wikidata: Q27291418
• NCI Thesaurus Code: C75101
• ChEMBL ID: CHEMBL542581
• Mol file: 956-90-1.mol

Synonyms:1-(1-Phenylcyclohexyl)piperidine;Angel Dust;CL 395;CL-395;CL395;Dust, Angel;GP 121;GP-121;GP121;Phencyclidine;Phencyclidine Hydrobromide;Phencyclidine Hydrochloride;Sernyl;Serylan

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Phencyclidine hydrochloride

Chemical Property:

• Vapor Pressure: 8.86E-05mmHg at 25°C
• Melting Point: 233-235°C
• Boiling Point: 340°C at 760 mmHg
• Flash Point: 144.5°C
• PSA: 3.24000
• LogP: 5.07180
• Storage Temp.: Store at RT
• Solubility.: H2O: 11.2 mg/mL
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 279.1753775
• Heavy Atom Count: 19
• Complexity: 242

Purity/Quality:

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)(C2=CC=CC=C2)N3CCCCC3.Cl
• Description: Phencyclidine hydrochloride (PCP) is a psychoactive drug that has inhibitory, excitatory, analgesic and hallucinogenic effects on the central nervous system. Its chemical name is 1-(1-phenylcyclohexane)piperidine. It is a dissociative drug once used by anesthesiologists as an anesthetic with hallucinogenic and neurotoxic effects.
• Uses: Controlled substance (depressant). Anesthetic (intravenous).

Technology Process of Phencyclidine hydrochloride

There total 2 articles about Phencyclidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromobenzene (108-86-1,52753-63-6) + 1-piperidinocyclohexylcarbonitrile (3867-15-0) → phencyclidine hydrochloride (956-90-1)

Guidance literature:

bromobenzene; With iodine; magnesium; In diethyl ether;

1-piperidinocyclohexylcarbonitrile; In tetrahydrofuran; diethyl ether;

With hydrogenchloride; In diethyl ether; water; isopropyl alcohol;

DOI:10.1016/j.pbb.2010.12.019

Reference yield:

piperidine (110-89-4) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → phencyclidine hydrochloride (956-90-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogensulfite

2: iodine; magnesium / diethyl ether

With iodine; sodium hydrogensulfite; magnesium; In diethyl ether;

DOI:10.1016/j.pbb.2010.12.019

Reference yield:

phencyclidine hydrochloride (956-90-1) → 1-(1-phenylcyclohexyl)-4-hydroxypiperidine (60232-85-1) + r-4-phenyl-4-(1-piperidinyl)-c-cyclohexanol (78165-07-8)

Guidance literature:

In water; for 312h; Title compound not separated from byproducts; Ambient temperature; Beauveria sulfurescens;

DOI:10.1002/jps.2600700210

upstream raw materials:

piperidine

cyclohexanone

bromobenzene

1-piperidinocyclohexylcarbonitrile

Downstream raw materials:

1-(1-phenylcyclohexyl)-4-hydroxypiperidine

r-4-phenyl-4-(1-piperidinyl)-t-cyclohexanol

r-4-phenyl-4-(1-piperidinyl)-c-cyclohexanol

Refernces