60232-85-1

Basic information

• Product Name: 1-(1-phenylcyclohexyl)-4-hydroxypiperidine
• Synonyms: 1-(1-phenylcyclohexyl)-4-hydroxypiperidine;1-(1-Phenylcyclohexyl)piperidine-4-ol;4-Hydroxy Phencyclidine;4-Hydroxy-1-(1-phenylcyclohexyl)piperidine;4-Hydroxyphencyclidine;N-(1-Phenylcyclohexyl)-4-hydroxypiperidine;NSC 170516;1-(1-phenylcyclohexyl)piperidin-4-ol
• CAS NO: 60232-85-1
• Molecular Formula: C₁₇H₂₅NO
• Molecular Weight: 259.39
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
• Mol File: 60232-85-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 116-118 °C(Solv: hexane (110-54-3); ethanol (64-17-5))
• Boiling Point: 400.9°C at 760 mmHg
• Flash Point: 106.1°C
• Appearance: /
• Density: 1.093g/cm³
• Vapor Pressure: 3.79E-07mmHg at 25°C
• Refractive Index: 1.574
• PKA: 14.86±0.20(Predicted)
• CAS DataBase Reference: 1-(1-phenylcyclohexyl)-4-hydroxypiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-phenylcyclohexyl)-4-hydroxypiperidine(60232-85-1)
• EPA Substance Registry System: 1-(1-phenylcyclohexyl)-4-hydroxypiperidine(60232-85-1)

Safety Data

• Hazardous Substances Data: 60232-85-1(Hazardous Substances Data)

Usage

Uses

4-Hydroxy Phencyclidine is a major monohydroxy metabolite of Phencyclidine (P295502) that produces PCP-like stimuli.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 24, p. 496, 1981 DOI: 10.1021/jm00137a004

InChI:InChI=1/C17H25NO/c19-16-9-13-18(14-10-16)17(11-5-2-6-12-17)15-7-3-1-4-8-15/h1,3-4,7-8,16,19H,2,5-6,9-14H2

Upstream product

• 108-86-1 bromobenzene 
• 60756-86-7 4-hydroxypiperidinocyclohexyl carbonitrile 
• 106-93-4 ethylene dibromide 
• 5382-17-2 piperidin-4-ol hydrochloride 
• 108-94-1 cyclohexanone 
• 956-90-1 phencyclidine hydrochloride 
• 77-10-1 Phencyclidine 
• 344260-33-9 1-(4-Trimethylsilanyloxy-piperidin-1-yl)-cyclohexanecarbonitrile 

Downstream Products

• 77179-36-3 Nicotinic acid 1-(1-phenyl-cyclohexyl)-piperidin-4-yl ester 
• 120807-81-0 1-(1-Phenyl-cyclohexyl)-4-trimethylsilanyloxy-piperidine 
• 77179-42-1 1-(1-phenylcyclohexyl)-4-piperidone 
• 77179-35-2 Benzoic acid 1-(1-phenyl-cyclohexyl)-piperidin-4-yl ester 
• 77179-38-5 1-(1-phenylcyclohexyl)-4-piperidyl acetate 
• 77179-37-4 4-Amino-benzoic acid 1-(1-phenyl-cyclohexyl)-piperidin-4-yl ester 
• 77179-34-1 3,4-Dimethoxy-benzoic acid 1-(1-phenyl-cyclohexyl)-piperidin-4-yl ester 
• 77179-39-6 1-(1-phenylcyclohexyl)-4-phenyl-4-piperidinol 
• 77179-40-9 1-(1-phenylcyclohexyl)-4-phenyl-4-piperidyl propionate 

Relevant articles and documents

IDENTIFICATION OF PHENCYCLIDINE METABOLITES BY THE METHOD OF CHROMATO-MASS SPECTROMETRY

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Synthesis and analgesic activity of new phencyclidine derivatives

New phencyclidine derivatives having structural similarities with the well known 4-phenylpiperidine narcotic analgesics were synthesized, characterized and their anti-nociceptive activity tested in mice by the hot-plate and tail-flick tests. Structure, activity relationships for these compounds further point to the importance of a second aryl moiety at position 4 of the piperidine ring of phencyclidine. In addition, the presence of a hydroxyl group in close proximate to the lipophilic moiety is vital for analgesic activity.

Application of chemical P450 model systems to studies on drug metabolism. I. Phencyclidine: A multi-functional model substrate

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