77179-42-1

Basic information

• Product Name: 1-(1-phenylcyclohexyl)-4-piperidone
• Synonyms: 1-(1-phenylcyclohexyl)-4-piperidone
• CAS NO: 77179-42-1
• Molecular Weight: 257.376
• Mol File: 77179-42-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(1-phenylcyclohexyl)-4-piperidone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-phenylcyclohexyl)-4-piperidone(77179-42-1)
• EPA Substance Registry System: 1-(1-phenylcyclohexyl)-4-piperidone(77179-42-1)

Safety Data

• Hazardous Substances Data: 77179-42-1(Hazardous Substances Data)

Upstream product

• 60232-85-1 1-(1-phenylcyclohexyl)-4-hydroxypiperidine 
• 7487-94-7 mercury (II) chloride 
• 6132-04-3 trisodium citrate dihydrate 
• 67-63-0 isopropyl alcohol 
• 7664-93-9 sulfuric acid 
• 344260-33-9 1-(4-Trimethylsilanyloxy-piperidin-1-yl)-cyclohexanecarbonitrile 

Downstream Products

• 139754-92-0 4-amino-1-(1-phenylcyclohexyl)-piperidine 
• 403806-31-5 C₁₇H₂₃NO*ClH 
• 77179-39-6 1-(1-phenylcyclohexyl)-4-phenyl-4-piperidinol 

Relevant articles and documents

Phencyclidine and phencyclidine metabolites assay, tracers, immunogens and antibodies

The present invention is directed to a fluorescence polarization assay for phencyclidine and phencyclidine derivatives, to the various components needed for preparing and carrying out such an assay, and to methods of making these components. Specifically, tracers, immunogens and antibodies are disclosed, as well as methods for making them. The tracers and the immunogens are made from substituted phencyclidine compounds. A fluorescein moiety is included in the tracer, while a poly(amino acid) forms a part of the immunogen. The assay is conducted by measuring the degree of polarization retention of plane polarized light that has been passed through a sample containing antiserum and tracer.

New Analgesic Drugs Derived from Phencyclidine

Several esters of 1-(1-phenylcyclohexyl)-4-piperidinol (3), 1-(1-phenylcyclohexyl)-4-phenyl-4-piperidinol (10) and its propionate (11), and 1-(1-phenylcyclohexyl)-4-phenylpiperidine (13) were prepared and characterized.The new compounds, which are derived from phencyclidine, exerted analgesic activity in mice.The most potent is 10, which is twice as active as morphine.The antinociceptive activity of 10, 11, and 13 could be well correlated with their potency in the mouse vas deferens bioassay, and both were completely reversed by naloxone.