2-methyl-1,4-diaminobutane

Base Information

• Chemical Name: 2-methyl-1,4-diaminobutane
• CAS No.: 15657-58-6
• Molecular Formula: C5H14N2
• Molecular Weight: 102.18
• Hs Code.: 2921290000
• Mol file: 15657-58-6.mol

Synonyms:2-Methyl-1,4-butanediamine;2-Methylputrescine;

Chemical Property of 2-methyl-1,4-diaminobutane

Chemical Property:

• Vapor Pressure: 2.37mmHg at 25°C
• Refractive Index: 1.455
• Boiling Point: 160.5°Cat760mmHg
• PKA: 10.44±0.10(Predicted)
• Flash Point: 54 ºC
• PSA: 52.04000
• Density: 0.860g/cm³
• LogP: 1.33060

Purity/Quality:

≥99.0% ^*data from raw suppliers

(R)-2-methylbutane-1,4-diamine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-methyl-1,4-diaminobutane

There total 13 articles about 2-methyl-1,4-diaminobutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-formylpyrrole-2-carboxylate (7126-57-0) → 2-methyl-1,4-butanediamine (15657-58-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / 10percent Pd/C / ethanol / 16 h / 2585.7 Torr

2: 73 percent / KOH / ethane-1,2-diol / 200 °C

3: 1.) Na₂CO₃, hydroxylamine hydrochloride, 2.) Na, EtOH / 1.) ethanol, reflux, 168 h, 2.) reflux, 4 h

With potassium hydroxide; ethanol; hydroxylamine hydrochloride; sodium; sodium carbonate; palladium on activated charcoal; In ethanol; ethylene glycol;

DOI:10.1021/jo00237a032

Reference yield:

2,4,5-triiodo-3-formylpyrrole (35302-95-5) → 2-methyl-1,4-butanediamine (15657-58-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / sodium acetate, H₂ / 10percent Pd/C / ethanol / 2 h / 2585.7 Torr

2: 42 percent / 80percent hydrazine hydrate, KOH / ethane-1,2-diol / 1.5 h / 200 °C

3: 1.) Na₂CO₃, hydroxylamine hydrochloride, 2.) Na, EtOH / 1.) ethanol, reflux, 168 h, 2.) reflux, 4 h

With potassium hydroxide; ethanol; hydroxylamine hydrochloride; hydrogen; sodium acetate; sodium; sodium carbonate; hydrazine hydrate; palladium on activated charcoal; In ethanol; ethylene glycol;

DOI:10.1021/jo00237a032

Reference yield:

methyl 1H-pyrrole-3-carboxylate (2703-17-5) → 2-methyl-1,4-butanediamine (15657-58-6)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrazine / 2 h / Heating

2: pyridine / 0.5 h / 20 °C

3: 15 percent / sodium carbonate / ethane-1,2-diol / 0.08 h / 170 °C

4: 42 percent / 80percent hydrazine hydrate, KOH / ethane-1,2-diol / 1.5 h / 200 °C

5: 1.) Na₂CO₃, hydroxylamine hydrochloride, 2.) Na, EtOH / 1.) ethanol, reflux, 168 h, 2.) reflux, 4 h

With pyridine; potassium hydroxide; ethanol; hydroxylamine hydrochloride; sodium; sodium carbonate; hydrazine hydrate; hydrazine; In ethylene glycol;

DOI:10.1021/jo00237a032

upstream raw materials:

3-methylpyrrole

2-methyl-1,4-butanediamide

3-methyl-1,6-adipamide

bromine

Downstream raw materials:

(R)-2-methyl-1,4-butanediamine dihydrochloride

NN'-dibenzoyl-2-methyl-1,4-diaminobutane

Refernces

• 1、 Kojima, Masaaki,Morita, Ken'ichi,Fujita, Junnosuke. "Preparation and Spectroscopic Studies of Cobalt(III) Complexes Containing Optically Active Seven-membered Chelate Ligands". . p. 2947 - 2955. Retrieved 2007/10/02.