5-Hydroxymethyl Flucloxacillin

Base Information

• Chemical Name: 5-Hydroxymethyl Flucloxacillin
• CAS No.: 75524-31-1
• Molecular Formula: C19H17 Cl F N3 O6 S
• Molecular Weight: 469.87
• Mol file: 75524-31-1.mol

Synonyms:4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-[[[3-(2-chloro-6-fluorophenyl)-5-(hydroxymethyl)-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,[2S-(2a,5a,6b)]-

Chemical Property of 5-Hydroxymethyl Flucloxacillin

Chemical Property:

• Vapor Pressure: 7.35E-23mmHg at 25°C
• Boiling Point: 737.9°C at 760 mmHg
• Flash Point: 400°C
• PSA: 158.27000
• Density: 1.67g/cm³
• LogP: 2.20050

Purity/Quality:

98% ^*data from raw suppliers

5-HYDROXY METHYL FLUCLOXACILLIN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Flucloxacillin A metabolite of Flucloxacillin.

Technology Process of 5-Hydroxymethyl Flucloxacillin

There total 2 articles about 5-Hydroxymethyl Flucloxacillin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

floxacillin (5250-39-5,24223-74-3) → 5-Hydroxymethylflucloxacillin (75524-31-1)

Guidance literature:

With glucose-6-phosphate dehydrogenase; glucose-6-phosphate; Bacillus megaterium CYP₁₀₂A₁ M₁₁ L₄₃₇E; NADPH; In aq. phosphate buffer; dimethyl sulfoxide; at 20 ℃; for 20h; pH=7.4; Enzymatic reaction;

DOI:10.1111/bph.14548

Reference yield:

Flucloxacillin sodium (1847-24-1) → 5-Hydroxymethylflucloxacillin (75524-31-1) + (5R)-flucloxacillin penicilloic acid (42947-70-6) + (5S)-flucloxacillin penicilloic acid (42947-70-6)

Guidance literature:

With metabolism in male albino rat;

DOI:10.1111/j.2042-7158.1985.tb04991.x

upstream raw materials:

Flucloxacillin sodium

floxacillin

Refernces

• 1、 Everett,Jennings,Woodnutt. "19F NMR spectroscopy study of the metabolites of flucloxacillin in rat urine". . p. 869 - 873. Retrieved 2007/10/02.