Flucloxacillin sodium

Base Information

• Chemical Name: Flucloxacillin sodium
• CAS No.: 1847-24-1
• Molecular Formula: C19H16ClFN3NaO5S
• Molecular Weight: 475.86
• Mol file: 1847-24-1.mol

Synonyms:4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid,6-[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-,sodium salt (7CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt, (2S,5R,6R)- (9CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,6-[[[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-,monosodium salt, [2S-(2a,5a,6b)]-;Floxacillin sodium;Floxapen;Floxapen sodium;Flucloxacillin sodium salt;Monosodium flucloxacillin;NSC 277175;Sodium[3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl]penicillin;Sodium flucloxacillin;Staphylex;Sodium 6-({[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;

Chemical Property of Flucloxacillin sodium

Chemical Property:

• Appearance/Colour: White solid
• Vapor Pressure: 2.86E-19mmHg at 25°C
• Melting Point: 176-178 °C
• Boiling Point: 677.3 °C at 760 mmHg
• Flash Point: 363.4 °C
• PSA: 140.87000
• LogP: 1.68190
• Storage Temp.: -20°C Freezer
• Sensitive.: Light Sensitive
• Solubility.: H2O: soluble20mg/mL, clear
• Water Solubility.: Soluble in water

Purity/Quality:

99% ^*data from raw suppliers

Flucloxacillin Sodium ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Antibacterial;Peptidoglycan synthesis inhibitor Flucloxacillin sodium has been used as a β-lactam antibiotic to study its effects on methicillin-resistant?Staphylococcus aureus?(MRSA) ΔfloA?mutant. Flucloxacillin, a new semisynthetic penicillin

Technology Process of Flucloxacillin sodium

There total 7 articles about Flucloxacillin sodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.6%

floxacillin (5250-39-5,24223-74-3) → Flucloxacillin sodium (1847-24-1)

Guidance literature:

With sodium isooctanoate; In ethyl acetate; Solvent;

Reference yield:

flushloxilin triethylamine → Flucloxacillin sodium (1847-24-1)

Guidance literature:

With sodium isooctanoate; In water; ethyl acetate; acetone; at 20 - 25 ℃; for 3h; Time;

Reference yield:

6-Aminopenicillanic Acid (551-16-6) + C18H10ClFN2O2S2 → Flucloxacillin sodium (1847-24-1)

Guidance literature:

6-Aminopenicillanic Acid; C₁₈H₁₀ClFN₂O₂S₂; With triethylamine; In dichloromethane; water; at 8 - 15 ℃; pH=6.5 - 8.5; Large scale;

With sodium acetate; In acetic acid butyl ester; at 20 - 35 ℃; for 0.5h; Large scale;

upstream raw materials:

2-chloro-6-fluorobenzaldehyde

6-Aminopenicillanic Acid

3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonyl chloride

3-(2-chloro-6-flourophenyl)-5-methyl-isoxazole-4-carboxylic acid

Downstream raw materials:

5-Hydroxymethylflucloxacillin

(5R)-flucloxacillin penicilloic acid

(5S)-flucloxacillin penicilloic acid

Refernces

• 1、 -. "Flucloxacillin sodium monohydrate synthetic method". Paragraph 0032-0036; 0038-0042; 0043-0047; 0048-0051. . Retrieved 2017/09/01.
• 2、 -. "IMPROVED PROCESS FOR PREPARING PENICILLINS AND INTERMEDIATE COMPOUNDS". . . Retrieved 2013/02/27.