3-fluoro-1-aminopyridinium mesitylenesulfonate

Base Information

• Chemical Name: 3-fluoro-1-aminopyridinium mesitylenesulfonate
• CAS No.: 886221-74-5
• Molecular Formula: C₅H₆FN₂*C₉H₁₁O₃S
• Molecular Weight: 312.365
• Mol file: 886221-74-5.mol

Synonyms:3-fluoro-1-aminopyridinium mesitylenesulfonate

Chemical Property of 3-fluoro-1-aminopyridinium mesitylenesulfonate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-fluoro-1-aminopyridinium mesitylenesulfonate

There total 4 articles about 3-fluoro-1-aminopyridinium mesitylenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

→ 3-fluoro-1-aminopyridinium mesitylenesulfonate (886221-74-5)

Guidance literature:

Reference yield:

3-Fluoropyridine (372-47-4) + mesitylenesulfonylhydroxylamine (36016-40-7) → 3-fluoro-1-aminopyridinium mesitylenesulfonate (886221-74-5)

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

Reference yield:

N-(tert-butoxycarbonyl)-O-(mesitylsulfonyl)hydroxylamine (36016-39-4) → 3-fluoro-1-aminopyridinium mesitylenesulfonate (886221-74-5)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / 0 °C / Inert atmosphere

2: dichloromethane / 0 °C / Inert atmosphere; Reflux

With trifluoroacetic acid; In dichloromethane;

DOI:10.1021/acs.orglett.2c00035

upstream raw materials:

3-Fluoropyridine

mesitylenesulfonylhydroxylamine

ethyl O-(2-mesitylenesulfonyl)acetohydroxamate

N-(tert-butoxycarbonyl)-O-(mesitylsulfonyl)hydroxylamine

Refernces

• 1、 -. "Heteroaryl imidazolone derivatives as jak inhibitors". Page/Page column 106-107. . Retrieved 2012/01/06.
• 2、 -. "PYRIMIDINE INHIBITORS OF KINASE ACTIVITY". Page/Page column 119-120. . Retrieved 2010/12/26.