2,4,5-trimethoxyphenyl-4'-methoxybenzyl ketone

Base Information

• Chemical Name: 2,4,5-trimethoxyphenyl-4'-methoxybenzyl ketone
• CAS No.: 5128-50-7
• Molecular Formula: C₁₈H₂₀O₅
• Molecular Weight: 316.354
• Mol file: 5128-50-7.mol

Synonyms:2,4,5-trimethoxyphenyl-4'-methoxybenzyl ketone

Chemical Property of 2,4,5-trimethoxyphenyl-4'-methoxybenzyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4,5-trimethoxyphenyl-4'-methoxybenzyl ketone

There total 7 articles about 2,4,5-trimethoxyphenyl-4'-methoxybenzyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-Methoxyphenylacetic acid (104-01-8) + 1,2,4-trimethoxy-benzene (135-77-3) → 2,4,5-trimethoxyphenyl-4'-methoxybenzyl ketone (5128-50-7)

Guidance literature:

4-Methoxyphenylacetic acid; 1,2,4-trimethoxy-benzene; With PPA; Polyphosphoric acid (PPA); at 70 ℃; for 1h;

With potassium carbonate; for 1.5h;

Reference yield:

p-methoxybenzylnitrile (104-47-2) → 2,4,5-trimethoxyphenyl-4'-methoxybenzyl ketone (5128-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ZnCl₂, HCl / diethyl ether

2: K₂CO₃

With hydrogenchloride; potassium carbonate; zinc(II) chloride; In diethyl ether;

DOI:10.1039/jr9600001491

Reference yield:

4',6,7-trimethoxy-isoflavone (798-61-8) → 2,4,5-trimethoxyphenyl-4'-methoxybenzyl ketone (5128-50-7)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / aq. ethanol

2: K₂CO₃

With potassium hydroxide; potassium carbonate; In ethanol;

DOI:10.1039/jr9600001491

upstream raw materials:

4-Methoxyphenylacetic acid

1,2,4-trimethoxy-benzene

4',6,7-trimethoxy-isoflavone

3,4-dimethoxyphenol

Downstream raw materials:

α-ethoxymethyl-2,4,5-trimetlhoxyphenyl-4'-methoxybenzyl ketone

2,4,5,4'-Tetramethoxy-benzil

Refernces