4-methoxy-cinnamic acid diethylamide

Base Information

• Chemical Name: 4-methoxy-cinnamic acid diethylamide
• CAS No.: 23784-83-0
• Molecular Formula: C₁₄H₁₉NO₂
• Molecular Weight: 233.31
• Mol file: 23784-83-0.mol

Synonyms:4-methoxy-cinnamic acid diethylamide

Chemical Property of 4-methoxy-cinnamic acid diethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methoxy-cinnamic acid diethylamide

There total 16 articles about 4-methoxy-cinnamic acid diethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

→ 4-methoxy-cinnamic acid diethylamide (23784-83-0)

Guidance literature:

With methanesulfonyl chloride;

for 24h; Reagent/catalyst; Reflux;

Reference yield: 89.0%

carbon monoxide (201230-82-2) + E-2'-p-methoxystyryl iodide (136618-41-2,119950-15-1) + diethylamine (109-89-7) → (E)-N,N-diethyl-3-(4-methoxyphenyl)propenamide (23784-83-0)

Guidance literature:

In acetonitrile; at 250 ℃; for 4h; under 30402 - 49403.3 Torr; Autoclave;

DOI:10.1021/acs.orglett.1c03714

Reference yield: 82.0%

N,N-diethyldichloroacetamide (921-88-0) + 4-methoxy-benzaldehyde (123-11-5) → (E)-N,N-diethyl-3-(4-methoxyphenyl)propenamide (23784-83-0)

Guidance literature:

With 2-phenylpyridine; manganese chloride bis(lithium chloride); lithium; In tetrahydrofuran; for 5h; Heating;

DOI:10.1021/jo701417z

upstream raw materials:

(E)-3-(4-methoxyphenyl)acrylic acid

2-bromo-N,N-diethylacetamide

4-methoxy-benzaldehyde

diethylamine

Downstream raw materials:

N,N-diethyl-4-methoxy-α-oxo-benzeneacetamide

Refernces

• 1、 Lai, Miao,Wu, Zhiyong,Su, Fangyao,Yu, Yujian,Jing, Yanqiu,Kong, Jinmin,Wang, Zhenteng,Wang, Shuai,Zhao, Mingqin. "Synthesis of Cinnamides via Amidation Reaction of Cinnamic Acids with Tetraalkylthiuram Disulfides Under Simple Condition". . p. 198 - 208. Retrieved 2020/01/22.
• 2、 -. "PIGMENT DISPERSION LIQUID, AND METHOD FOR PRODUCING PHOTOSENSITIVE RESIN COMPOSITION USING THE SAME". Paragraph 0154-0155. . Retrieved 2020/10/09.