Technology Process of 5-[benzyloxy(3,4,5-trimethoxyphenyl)-methyl]-6-[1,3]dioxolan-2-yl-benzo[1,3]-dioxole
There total 3 articles about 5-[benzyloxy(3,4,5-trimethoxyphenyl)-methyl]-6-[1,3]dioxolan-2-yl-benzo[1,3]-dioxole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C
1.2: 75 percent / tetrahydrofuran; hexane / -78 - 0 °C
2.1: 71 percent / NaH; KI / tetrahydrofuran / 18 h / 20 °C
With
n-butyllithium; sodium hydride; potassium iodide;
In
tetrahydrofuran; hexane;
DOI:10.1021/jo052599x
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 84 percent / p-TsOH / benzene / 26 h / Heating
2.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C
2.2: 75 percent / tetrahydrofuran; hexane / -78 - 0 °C
3.1: 71 percent / NaH; KI / tetrahydrofuran / 18 h / 20 °C
With
n-butyllithium; sodium hydride; toluene-4-sulfonic acid; potassium iodide;
In
tetrahydrofuran; hexane; benzene;
DOI:10.1021/jo052599x
- Guidance literature:
-
α-2-<(1,3-dioxolan-2-yl)-4,5-methylenedioxyphenyl>-3,4,5-trimethoxybenzyl alcohol;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
for 0.5h;
benzyl halide;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
for 18h;
DOI:10.1002/chem.201101909