2-(carboxymethyl)-4-methoxybenzoic acid

Base Information

• Chemical Name: 2-(carboxymethyl)-4-methoxybenzoic acid
• CAS No.: 68294-03-1
• Molecular Formula: C₁₀H₁₀O₅
• Molecular Weight: 210.186
• Mol file: 68294-03-1.mol

Synonyms:2-(carboxymethyl)-4-methoxybenzoic acid

Chemical Property of 2-(carboxymethyl)-4-methoxybenzoic acid

Chemical Property:

• Melting Point: 222 °C
• Boiling Point: 409.4±30.0 °C(Predicted)
• PKA: 4.03±0.36(Predicted)
• Density: 1.370±0.06 g/cm3(Predicted)

Purity/Quality:

2-(Carboxymethyl)-4-methoxybenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(carboxymethyl)-4-methoxybenzoic acid

There total 13 articles about 2-(carboxymethyl)-4-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-methoxy-indan-1,2-dione 2-oxime (7235-36-1) → 2-(carboxymethyl)-4-methoxybenzoic acid (68294-03-1)

Guidance literature:

With sodium hydroxide; p-toluenesulfonyl chloride; for 1h; Heating;

DOI:10.1071/CH01114

Reference yield:

5-methoxy-1-indanone (5111-70-6) → 4-methoxyphthalic acid (1885-13-8) + 2-(carboxymethyl)-4-methoxybenzoic acid (68294-03-1)

Guidance literature:

Reference yield:

4-methoxy-2-methylbenzoic acid (6245-57-4) + carbonic acid dimethyl ester (616-38-6) → 2-(carboxymethyl)-4-methoxybenzoic acid (68294-03-1)

Guidance literature:

4-methoxy-2-methylbenzoic acid; carbonic acid dimethyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at 20 ℃; for 4h;

With hydrogenchloride; water; pH=2;

DOI:10.1021/jm800072z

upstream raw materials:

5-methoxy-1H-indene

6-methoxy-1H-indene

2-cyanomethyl-4-methoxy-benzoic acid

5-methoxy-1-indanone

Downstream raw materials:

sodium methylate

3,4-Dihydro-6-methoxy-2-phenylnaphthalene

6-Methoxyisochroman-3-one

6-methoxy-3-methylisoquinolin-1(2H)-one

Refernces

• 1、 Kang, Bo-Rui,Wang, Juan,Li, Huan,Li, Yan,Mei, Qi-Bing,Zhang, San-Qi. "Synthesis and antitumor activity evaluation of 2-arylisoquinoline-1,3(2H, 4H)-diones in vitro and in vivo". . p. 1340 - 1349. Retrieved 2014/03/21.
• 2、 -. "1-ARYL-4-SUBSTITUTED ISOQUINOLINES". Page/Page column 55-56. . Retrieved 2010/02/14.