C₁₈H₂₅ClN₅OP

Base Information

• Chemical Name: C₁₈H₂₅ClN₅OP
• CAS No.: 1407520-08-4
• Molecular Formula: C₁₈H₂₅ClN₅OP
• Molecular Weight: 393.856
• Mol file: 1407520-08-4.mol

Synonyms:C₁₈H₂₅ClN₅OP

Chemical Property of C₁₈H₂₅ClN₅OP

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₂₅ClN₅OP

There total 3 articles about C₁₈H₂₅ClN₅OP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1,3-diaminocyclohexane (3385-21-5,26772-34-9,26883-70-5,115092-57-4) + (2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethyl phosphine oxide (1197953-49-3) → C18H25ClN5OP (1407520-08-4)

Guidance literature:

With hydrogenchloride; In ethanol; 2-methoxy-ethanol; at 110 ℃; Sealed tube;

Reference yield:

2-iodophenylamine (615-43-0) → C18H25ClN5OP (1407520-08-4)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium phosphate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide / 3 h / 150 °C

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

3: hydrogenchloride / ethanol; 2-methoxy-ethanol / 110 °C / Sealed tube

With hydrogenchloride; potassium phosphate; potassium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In ethanol; 2-methoxy-ethanol; N,N-dimethyl-formamide;

Reference yield:

(2-aminophenyl)dimethyl phosphorus oxide (1197953-47-1) → C18H25ClN5OP (1407520-08-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

2: hydrogenchloride / ethanol; 2-methoxy-ethanol / 110 °C / Sealed tube

With hydrogenchloride; potassium carbonate; In ethanol; 2-methoxy-ethanol; N,N-dimethyl-formamide;

upstream raw materials:

2-iodophenylamine

1,3-diaminocyclohexane

(2-((2,5-dichloropyrimidin-4-yl)amino)phenyl)dimethyl phosphine oxide

(2-aminophenyl)dimethyl phosphorus oxide

Refernces

• 1、 -. "COMPOUNDS FOR INHIBITING CELL PROLIFERATION IN EGFR-DRIVEN CANCERS". . . Retrieved 2012/11/14.