N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^δ-carbobenzoxy-L-ornithine

Base Information

• Chemical Name: N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^δ-carbobenzoxy-L-ornithine
• CAS No.: 80407-74-5
• Molecular Formula: C₂₈H₃₁N₉O₅
• Molecular Weight: 573.611
• Mol file: 80407-74-5.mol

Synonyms:N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^δ-carbobenzoxy-L-ornithine

Chemical Property of N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^δ-carbobenzoxy-L-ornithine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^δ-carbobenzoxy-L-ornithine

There total 5 articles about N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^δ-carbobenzoxy-L-ornithine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

Nα-(4-amino-4-deoxy-N10-methylpteroyl)-Nδ-carbobenzoxy-L-ornithine tert-butyl ester (80407-76-7) → Nα-(4-amino-4-deoxy-N10-methylpteroyl)-Nδ-carbobenzoxy-L-ornithine (80407-74-5)

Guidance literature:

With trifluoroacetic acid; for 6h; Ambient temperature;

DOI:10.1021/jm00346a026

Reference yield:

4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride (56892-71-8) → Nα-(4-amino-4-deoxy-N10-methylpteroyl)-Nδ-carbobenzoxy-L-ornithine (80407-74-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine / various solvent(s) / 1 h / 60 °C

2: 86 percent / 70percent aq. trifluoroacetic acid / 6 h / Ambient temperature

With 4-methyl-morpholine; trifluoroacetic acid; In various solvent(s);

DOI:10.1021/jm00346a026

Reference yield:

4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid (19741-14-1) → Nα-(4-amino-4-deoxy-N10-methylpteroyl)-Nδ-carbobenzoxy-L-ornithine (80407-74-5)

Guidance literature:

Multi-step reaction with 3 steps

1: N-methylmorpholine / various solvent(s) / 0.33 h / 0 °C

2: N-methylmorpholine / various solvent(s) / 1 h / 60 °C

3: 86 percent / 70percent aq. trifluoroacetic acid / 6 h / Ambient temperature

With 4-methyl-morpholine; trifluoroacetic acid; In various solvent(s);

DOI:10.1021/jm00346a026

upstream raw materials:

N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^δ-carbobenzoxy-L-ornithine tert-butyl ester

4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride

4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid

(S)-2-amino-5-(((benzyloxy)carbonyl)amino)pentanoic acid tert-butyl ester

Downstream raw materials:

N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-ornithine

Refernces