56892-71-8Relevant articles and documents
Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase
Abraham,McGuire,Galivan,Nimec,Kisliuk,Gaumont,Nair
, p. 222 - 227 (2007/10/02)
Five analogues of methotrextate (MTX), 10-deazaaminopterin (10-DAM), and 10-ethyl-10-deazaaminopterin (10-EDAM) in which the glutamate moiety was replaced by either a γ-methyleneglutamate or β-hydroxyglutamate were synthesized and evaluated for their anti
Lysine and Ornithine Analogues of Methotrexate as Inhibitors of Dihydrofolate Reductase
Kempton, Robert J.,Black, Angelique M.,Anstead, Gregory M.,Kumar, A. Ashok,Blankenship, Dale T.,Freisheim, James H.
, p. 475 - 477 (2007/10/02)
The ornithine (6a) and lysine (6b) analogues of methotrexate (1) have been synthesized via condensation of 4-amino-4-deoxy-N10-methylpteroic acid (2) with Nδ-carbobenzoxy-L-ornithine tert-butyl ester (3a) and Nε-carbobenzo