124126-66-5

Basic information

• Product Name: α-tert-butyl 4-amino-4-deoxy-N¹⁰-methylpteroyltetraglutamate
• Synonyms: α-tert-butyl 4-amino-4-deoxy-N¹⁰-methylpteroyltetraglutamate
• CAS NO: 124126-66-5
• Molecular Weight: 1066.22
• Mol File: 124126-66-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: α-tert-butyl 4-amino-4-deoxy-N¹⁰-methylpteroyltetraglutamate(CAS DataBase Reference)
• NIST Chemistry Reference: α-tert-butyl 4-amino-4-deoxy-N¹⁰-methylpteroyltetraglutamate(124126-66-5)
• EPA Substance Registry System: α-tert-butyl 4-amino-4-deoxy-N¹⁰-methylpteroyltetraglutamate(124126-66-5)

Safety Data

• Hazardous Substances Data: 124126-66-5(Hazardous Substances Data)

Upstream product

• 84793-07-7 Fmoc-Glu-OtBu 
• 56892-71-8 4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride 
• 124126-68-7 α-tert-butyl N-<(9-fluorenylmethoxy)oxy>carbonyl-L-glutamic anhydride 
• 19741-14-1 4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid 
• 45120-30-7 L-glutamic acid α-tert-butyl ester 

Downstream Products

• 73610-81-8 N-methylamino>benzoyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamyl>-L-γ-glutamic acid 

Relevant articles and documents

Folate analogues. 33. Synthesis of folate and antifolate poly-γ-glutamates by [(9-fluorenylmethoxy)oxy]carbonyl chemistry and biological evaluation of certain methotrexate polyglutamate polylysine conjugates as inhibitors of the growth of H35 hepatoma cel

Representative examples of folate and antifolate poly-γ-glutamyl metabolites were synthesized via the [(9-fluorenylmethoxy)oxy]carbonyl (Fmoc) chemistry using the KH polyamide resin. Polyglutamate yields were consistently better in all cases compared to t