1-butoxy-2-fluorobenzene

Base Information

• Chemical Name: 1-butoxy-2-fluorobenzene
• CAS No.: 20781-61-7
• Molecular Formula: C₁₀H₁₃FO
• Molecular Weight: 168.211
• Mol file: 20781-61-7.mol

Synonyms:1-butoxy-2-fluorobenzene

Chemical Property of 1-butoxy-2-fluorobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-butoxy-2-fluorobenzene

There total 3 articles about 1-butoxy-2-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

potassium (4-butoxyphenyl)trifluoroborate (850623-61-9) → 4-fluorobenzyl-n-butylether (78649-25-9) + 1-butoxy-2-fluorobenzene (20781-61-7)

Guidance literature:

With iron(III) chloride; potassium fluoride; Selectfluor; In ethyl acetate; at 55 ℃; Overall yield = 75 %Spectr.;

DOI:10.1055/s-0034-1379942

Reference yield:

n-butyl phenyl ether (1126-79-0) → 4-fluorobenzyl-n-butylether (78649-25-9) + 1-butoxy-2-fluorobenzene (20781-61-7)

Guidance literature:

With caesium fluoroxysulphate; boron trifluoride; In acetonitrile; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1039/c39810000148

Reference yield:

o-fluoro-benzoic acid (445-29-4) → 1-butoxy-2-fluorobenzene (20781-61-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / ethanol / 20 °C

2: oxygen; copper diacetate; silver carbonate / N,N-dimethyl-formamide / 18 h / 145 °C

With potassium tert-butylate; oxygen; copper diacetate; silver carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/ja304539j

upstream raw materials:

n-butyl phenyl ether

o-fluoro-benzoic acid

potassium (4-butoxyphenyl)trifluoroborate

Downstream raw materials:

(4-Butoxy-3-fluoro-phenyl)-acetic acid ethyl ester

Ethyl 4-n-Butoxy-3-fluorocinnamate

4-n-Butoxy-3-fluorocinnamahydroxamic acid

4-n-Butoxy-3-fluorobenzaldehyde

Refernces

• 1、 Stavber, Stojan,Zupan, Marko. "Caesium Fluoroxysulphate as a Mild Fluorinating Agent for the Fluorination of Alkoxy-substituted Benzene and Naphthalene Derivatives". . p. 148. Retrieved 1981.