4-nitro-N-α-acetylphenylalanine

Base Information

• Chemical Name: 4-nitro-N-α-acetylphenylalanine
• CAS No.: 61925-80-2
• Molecular Formula: C₁₁H₁₃N₃O₄
• Molecular Weight: 251.242
• Mol file: 61925-80-2.mol

Synonyms:4-nitro-N-α-acetylphenylalanine

Chemical Property of 4-nitro-N-α-acetylphenylalanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-nitro-N-α-acetylphenylalanine

There total 6 articles about 4-nitro-N-α-acetylphenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → 4-nitro-N-α-acetylphenylalanine (61925-80-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 24 percent / conc. HNO₃, conc. H₂SO₄ / 3.5 h / -10 °C

2: 58 percent / NaOH / 2-methyl-propan-2-ol; H₂O / 25 °C

3: 61 percent / DCC / tetrahydrofuran / 25 °C

4: 95 percent / conc. NH₄OH / tetrahydrofuran / 25 °C

5: TFA / 1 h

6: 0.20 g / glacial HOAc / 0.25 h / 90 °C

With ammonium hydroxide; sodium hydroxide; sulfuric acid; nitric acid; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; water; tert-butyl alcohol;

DOI:10.1021/jm00117a015

Reference yield:

4-nitrophenylalanine (1991-83-9,2922-40-9,56613-61-7,949-99-5) → 4-nitro-N-α-acetylphenylalanine (61925-80-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 58 percent / NaOH / 2-methyl-propan-2-ol; H₂O / 25 °C

2: 61 percent / DCC / tetrahydrofuran / 25 °C

3: 95 percent / conc. NH₄OH / tetrahydrofuran / 25 °C

4: TFA / 1 h

5: 0.20 g / glacial HOAc / 0.25 h / 90 °C

With ammonium hydroxide; sodium hydroxide; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; water; tert-butyl alcohol;

DOI:10.1021/jm00117a015

Reference yield:

2-tert-butoxycarbonylamino-3-(4-nitro-phenyl)-propionic acid (86937-80-6) → 4-nitro-N-α-acetylphenylalanine (61925-80-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 61 percent / DCC / tetrahydrofuran / 25 °C

2: 95 percent / conc. NH₄OH / tetrahydrofuran / 25 °C

3: TFA / 1 h

4: 0.20 g / glacial HOAc / 0.25 h / 90 °C

With ammonium hydroxide; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran;

DOI:10.1021/jm00117a015

upstream raw materials:

2-amino-3-(4-nitrophenyl)propanamide

acetic anhydride

L-phenylalanine

4-nitrophenylalanine

Downstream raw materials:

4-amino-N-acetylphenylalanine amide

Refernces