Technology Process of Chlorthalidone
There total 10 articles about Chlorthalidone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dihydrogen peroxide; sodium hydroxide;
In
water;
at 0 - 26 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: zinc; acetic acid / 70 - 75 °C
2.1: chlorosulfonic acid / 0 - 80 °C
2.2: 2 h / 75 - 80 °C
3.1: ammonium hydroxide / acetone; water / 0 - 5 °C
4.1: dihydrogen peroxide; sodium hydroxide / water / 0 - 26 °C
With
chlorosulfonic acid; ammonium hydroxide; dihydrogen peroxide; acetic acid; sodium hydroxide; zinc;
In
water; acetone;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide; hydroxylamine hydrochloride / methanol / 25 - 65 °C
2.1: zinc; acetic acid / 70 - 75 °C
3.1: chlorosulfonic acid / 0 - 80 °C
3.2: 2 h / 75 - 80 °C
4.1: ammonium hydroxide / acetone; water / 0 - 5 °C
5.1: dihydrogen peroxide; sodium hydroxide / water / 0 - 26 °C
With
chlorosulfonic acid; ammonium hydroxide; hydroxylamine hydrochloride; dihydrogen peroxide; acetic acid; sodium hydroxide; zinc;
In
methanol; water; acetone;