Technology Process of 2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidine-4,6-diamine
There total 7 articles about 2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidine-4,6-diamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bis(tri-n-butyltin);
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane;
Inert atmosphere;
Reflux;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: zinc; acetic acid / methanol / 24 h / Reflux
2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.5 h / 0 °C
3.1: hydrazine hydrate / ethylene glycol / 4 h / Reflux
4.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0 °C
4.2: 0.5 h / -10 °C
4.3: 0 - 20 °C
5.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
6.1: bis(tri-n-butyltin) / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / Inert atmosphere; Reflux
With
boron trifluoride diethyl etherate; bis(tri-n-butyltin); caesium carbonate; hydrazine hydrate; acetic acid; triethylamine; trifluoroacetic anhydride; zinc;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethylene glycol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sulfuric acid / 1 h / 60 - 65 °C
1.2: 20 °C / Cooling
2.1: zinc; acetic acid / methanol / 24 h / Reflux
3.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.5 h / 0 °C
4.1: hydrazine hydrate / ethylene glycol / 4 h / Reflux
5.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0 °C
5.2: 0.5 h / -10 °C
5.3: 0 - 20 °C
6.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
7.1: bis(tri-n-butyltin) / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / Inert atmosphere; Reflux
With
sulfuric acid; boron trifluoride diethyl etherate; bis(tri-n-butyltin); caesium carbonate; hydrazine hydrate; acetic acid; triethylamine; trifluoroacetic anhydride; zinc;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethylene glycol; N,N-dimethyl-formamide;