2-Chloro-5-fluoronicotinonitrile

Base Information

• Chemical Name: 2-Chloro-5-fluoronicotinonitrile
• CAS No.: 791644-48-9
• Molecular Formula: C6H2ClFN2
• Molecular Weight: 156.547
• Hs Code.: 2933399090
• Mol file: 791644-48-9.mol

Synonyms:2-Chloro-5-fluoronicotinonitrile;

Chemical Property of 2-Chloro-5-fluoronicotinonitrile

Chemical Property:

• Boiling Point: 235.2 °C at 760 mmHg
• PKA: -4.51±0.10(Predicted)
• Flash Point: 96.1 °C
• PSA: 36.68000
• Density: 1.43 g/cm³
• LogP: 1.74578
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%, ^*data from raw suppliers

2-Chloro-5-fluoronicotinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-5-fluoronicotinonitrile

There total 11 articles about 2-Chloro-5-fluoronicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-chloro-5-fluoropyridine-3-carboxamide (75302-64-6) → 2-chloro-5-fluoronicotinonitrile (791644-48-9)

Guidance literature:

With triethylamine; trifluoroacetic anhydride; In dichloromethane; at 0 ℃; for 1h;

Reference yield: 89.5%

2-chloro-5-fluoropyridine-3-carbaldehyde (851484-95-2) → 2-chloro-5-fluoronicotinonitrile (791644-48-9)

Guidance literature:

2-chloro-5-fluoropyridine-3-carbaldehyde; With hydroxylamine hydrochloride; In ethanol; water; at 20 ℃; for 1h;

With 1,1'-carbonyldiimidazole; In dichloromethane; for 1h; Inert atmosphere; Reflux;

Reference yield: 52.0%

→ 2-chloro-5-fluoronicotinonitrile (791644-48-9)

Guidance literature:

upstream raw materials:

2-chloro-5-fluoropyridine-3-carboxamide

2-chloro-5-fluoronicotinic acid

2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid

2,6-dichloro-5-fluoropyridine-3-carboxamide

Downstream raw materials:

5-fluoro-3-iodo-1H-pyrazolo[3,4-b]pyridine

5-fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine

2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-nitropyrimidine-4,6-diamine

5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile

Refernces

• 1、 -. "Pyrazolopyridine compound and use thereof". Paragraph 0373; 0374. . Retrieved 2018/11/03.
• 2、 -. "BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT， AMELIORATION OR PREVENTION OF INFLUENZA". Page/Page column 63. . Retrieved 2017/12/27.