Technology Process of (1R,4R,5R,8S)-4-[4-(1,1-dimethylheptyl)-2-methoxyphenyl]-8-methoxymethoxybicyclo[3.3.1]non-3-en-2-one
There total 14 articles about (1R,4R,5R,8S)-4-[4-(1,1-dimethylheptyl)-2-methoxyphenyl]-8-methoxymethoxybicyclo[3.3.1]non-3-en-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
DOI:10.1021/ol051570c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 100 percent / H2; Et3N / Pd/C / methanol / 120 h / 20 °C
2.1: 87 percent / Br2; AcOH / 4 h / 20 °C
3.1: Mg; I2 / tetrahydrofuran / 1.33 h / Heating
3.2: HMPA; CuBr*Me2S / tetrahydrofuran / 2 h / -78 °C
4.1: 638 mg / TBAF / tetrahydrofuran / 0.5 h / 20 °C
With
tetrabutyl ammonium fluoride; hydrogen; bromine; iodine; magnesium; acetic acid; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol;
DOI:10.1021/ol051570c
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 82 percent / H2; Et3N / Pd/C / methanol / 192 h / 20 °C / atmospheric pressure
2.1: 68 percent / 1-propanethiol; NaH / dimethylformamide / 20 h / 120 °C
3.1: 87 percent / 2,4,6-collidine / CH2Cl2 / 24 h / 0 °C
4.1: 100 percent / H2; Et3N / Pd/C / methanol / 120 h / 20 °C
5.1: 87 percent / Br2; AcOH / 4 h / 20 °C
6.1: Mg; I2 / tetrahydrofuran / 1.33 h / Heating
6.2: HMPA; CuBr*Me2S / tetrahydrofuran / 2 h / -78 °C
7.1: 638 mg / TBAF / tetrahydrofuran / 0.5 h / 20 °C
With
2,4,6-trimethyl-pyridine; 1-thiopropane; tetrabutyl ammonium fluoride; hydrogen; bromine; iodine; sodium hydride; magnesium; acetic acid; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol051570c