Technology Process of (7R,8R)-7-[4-(1,1-dimethylheptyl)-2-methoxyphenyl]-8-(2-[1,3]dioxolan-2-ylethyl)-1,4-dioxaspiro[4,5]decane
There total 10 articles about (7R,8R)-7-[4-(1,1-dimethylheptyl)-2-methoxyphenyl]-8-(2-[1,3]dioxolan-2-ylethyl)-1,4-dioxaspiro[4,5]decane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
xylene;
for 1h;
Heating;
DOI:10.1021/ol051570c
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 100 percent / H2; Et3N / Pd/C / methanol / 120 h / 20 °C
2.1: 87 percent / Br2; AcOH / 4 h / 20 °C
3.1: Mg; I2 / tetrahydrofuran / 1.33 h / Heating
3.2: HMPA; CuBr*Me2S / tetrahydrofuran / 2 h / -78 °C
4.1: 638 mg / TBAF / tetrahydrofuran / 0.5 h / 20 °C
5.1: 88 percent / TsOH / xylene / 1 h / Heating
With
tetrabutyl ammonium fluoride; hydrogen; bromine; iodine; toluene-4-sulfonic acid; magnesium; acetic acid; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; xylene;
DOI:10.1021/ol051570c
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 82 percent / H2; Et3N / Pd/C / methanol / 192 h / 20 °C / atmospheric pressure
2.1: 68 percent / 1-propanethiol; NaH / dimethylformamide / 20 h / 120 °C
3.1: 87 percent / 2,4,6-collidine / CH2Cl2 / 24 h / 0 °C
4.1: 100 percent / H2; Et3N / Pd/C / methanol / 120 h / 20 °C
5.1: 87 percent / Br2; AcOH / 4 h / 20 °C
6.1: Mg; I2 / tetrahydrofuran / 1.33 h / Heating
6.2: HMPA; CuBr*Me2S / tetrahydrofuran / 2 h / -78 °C
7.1: 638 mg / TBAF / tetrahydrofuran / 0.5 h / 20 °C
8.1: 88 percent / TsOH / xylene / 1 h / Heating
With
2,4,6-trimethyl-pyridine; 1-thiopropane; tetrabutyl ammonium fluoride; hydrogen; bromine; iodine; sodium hydride; toluene-4-sulfonic acid; magnesium; acetic acid; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; xylene;
DOI:10.1021/ol051570c