Tolperisone

Base Information Edit

Chemical Name:Tolperisone
CAS No.:728-88-1
Molecular Formula:C₁₆H₂₃NO
Molecular Weight:245.365
Hs Code.:
European Community (EC) Number:211-976-4
NSC Number:107321
UNII:F5EOM0LD8E
DSSTox Substance ID:DTXSID8023686
Nikkaji Number:J6.952C
Wikipedia:Tolperisone
Wikidata:Q369648
NCI Thesaurus Code:C84219
Pharos Ligand ID:R9UU6S13KSBP
Metabolomics Workbench ID:144843
ChEMBL ID:CHEMBL1076211
Mol file:728-88-1.mol

Synonyms:Hydrochloride, Tolperisone;Midocalm;Mydeton;Mydocalm;Tolperisone;Tolperisone Hydrochloride

Suppliers and Price of Tolperisone

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
TOLPERISONE 95.00%
1KG
$ 6985.44

Total 48 raw suppliers

Chemical Property of Tolperisone Edit

Chemical Property:

Vapor Pressure:8.66E-06mmHg at 25°C
Melting Point:176.5°C
Refractive Index:1.5500 (estimate)
Boiling Point:373.9°C at 760 mmHg
PKA:8.47±0.10(Predicted)
Flash Point:134.4°C
PSA：20.31000
Density:1.004g/cm³
LogP:3.23760
XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:245.177964357
Heavy Atom Count:18
Complexity:262

Purity/Quality:

99.9% ^*data from raw suppliers

TOLPERISONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C(=O)C(C)CN2CCCCC2
Recent ClinicalTrials:Tolperisone in Acute Muscle Spasm of the Back
Recent EU Clinical Trials:A randomized, multicenter, double-blind, parallel study to compare the efficacy and safety profile of RGH-507 (tolperisone-containing) gel versus a ketoprofen-containing gel in the treatment of patients with soft tissue injuries.

Technology Process of Tolperisone

There total 8 articles about Tolperisone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 5337-93-9
4'-methylpropiophenone

: 6091-44-7
piperidine hydrochloride

: 728-88-1,67499-64-3
tolperisone

Guidance literature:: With 1,3-DIOXOLANE; at 80 ℃; for 24h; Sealed tube;

Reference yield: 90.0%

: 3',5'-dibromo-tolperisone

: 728-88-1,67499-64-3
tolperisone

Guidance literature:: With hydrogen; triethylamine; palladium on activated charcoal; In ethanol; for 1.5h;
DOI:10.1002/(SICI)1099-1344(199912)42:12<1125::AID-JLCR266>3.0.CO;2-9