4-cycloheptyl-3-oxo-2-(triphenyl-λ⁵phosphatylidene)butyric acid ethyl ester

Base Information

• Chemical Name: 4-cycloheptyl-3-oxo-2-(triphenyl-λ⁵phosphatylidene)butyric acid ethyl ester
• CAS No.: 869584-17-8
• Molecular Formula: C₃₁H₃₅O₃P
• Molecular Weight: 486.591
• Mol file: 869584-17-8.mol

Synonyms:4-cycloheptyl-3-oxo-2-(triphenyl-λ⁵phosphatylidene)butyric acid ethyl ester

Chemical Property of 4-cycloheptyl-3-oxo-2-(triphenyl-λ⁵phosphatylidene)butyric acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-cycloheptyl-3-oxo-2-(triphenyl-λ⁵phosphatylidene)butyric acid ethyl ester

There total 1 articles about 4-cycloheptyl-3-oxo-2-(triphenyl-λ⁵phosphatylidene)butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-cycloheptylacetic acid (4401-20-1) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → 4-cycloheptyl-3-oxo-2-(triphenyl-λ5phosphatylidene)butyric acid ethyl ester (869584-17-8)

Guidance literature:

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 - 20 ℃; for 17h;

DOI:10.1021/jm049069y

Reference yield:

4-cycloheptyl-3-oxo-2-(triphenyl-λ5phosphatylidene)butyric acid ethyl ester (869584-17-8) → 3-[(5-cycloheptylmethyl-2-naphthalen-2-yl-1H-imidazole-4-carbonyl)-amino]-benzoic acid

Guidance literature:

Multi-step reaction with 5 steps

1: 88 percent / Oxone / tetrahydrofuran; H₂O / 16 h / 20 °C

2: 40 percent / NH₄OAc; AcOH / 2 h / 70 °C

3: 96 percent / aq. NaOH / ethanol / 48 h / Heating

4: HOBT; DMAP; EDC / dimethylformamide / 20 °C

5: H₂ / Pd/C / tetrahydrofuran; methanol

With dmap; Oxone; sodium hydroxide; ammonium acetate; hydrogen; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm049069y

Reference yield:

4-cycloheptyl-3-oxo-2-(triphenyl-λ5phosphatylidene)butyric acid ethyl ester (869584-17-8) → 5-((5-cycloheptylmethyl-2-phenyl-1H-imidazole-4-carbonyl)amino)isophthalic acid

Guidance literature:

Multi-step reaction with 5 steps

1: 88 percent / Oxone / tetrahydrofuran; H₂O / 16 h / 20 °C

2: NH₄OAc; AcOH / 70 °C

3: aq. NaOH / ethanol / Heating

4: HOBT; DMAP; EDC / dimethylformamide / 20 °C

5: H₂ / Pd/C / tetrahydrofuran; methanol

With dmap; Oxone; sodium hydroxide; ammonium acetate; hydrogen; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm049069y

upstream raw materials:

2-cycloheptylacetic acid

ethyl (triphenylphosphoranylidene)acetate

Downstream raw materials:

5-cycloheptylmethyl-2-phenyl-1H-imidazole-4-carboxylic acid

5-cycloheptylmethyl-2-phenyl-1H-imidazole-4-carboxylic acid ethyl ester

3-[(5-cycloheptylmethyl-2-naphthalen-2-yl-1H-imidazole-4-carbonyl)-amino]-benzoic acid benzyl ester

5-cycloheptylmethyl-2-naphthalen-2-yl-1H-imidazole-4-carboxylic acid (3,5-(dimethoxycarbonyloxymethyl)phenyl)amide

Refernces