methyl 3-(N,N-dimethylamino)benzoate-N-oxide

Base Information

• Chemical Name: methyl 3-(N,N-dimethylamino)benzoate-N-oxide
• CAS No.: 1616786-25-4
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.218
• Mol file: 1616786-25-4.mol

Synonyms:methyl 3-(N,N-dimethylamino)benzoate-N-oxide

Chemical Property of methyl 3-(N,N-dimethylamino)benzoate-N-oxide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of methyl 3-(N,N-dimethylamino)benzoate-N-oxide

There total 1 articles about methyl 3-(N,N-dimethylamino)benzoate-N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(dimethylamino)benzoic acid methyl ester (16518-64-2) → methyl 3-(N,N-dimethylamino)benzoate-N-oxide (1616786-25-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 23 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol501813s

Reference yield: 63.0%

methyl 3-(N,N-dimethylamino)benzoate-N-oxide (1616786-25-4) + p-toluenesulfonyl chloride (98-59-9) → methyl 3-(N,N-dimethylamino)-4-(p-toluenesulfonate)benzoate (1616786-40-3)

Guidance literature:

methyl 3-(N,N-dimethylamino)benzoate-N-oxide; p-toluenesulfonyl chloride; In dichloromethane; at -78 - 23 ℃; for 2h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - 23 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/ol501813s

Reference yield:

methyl 3-(N,N-dimethylamino)benzoate-N-oxide (1616786-25-4) → methyl 2-hydroxy-3-(N,N-dimethylamino)benzoate (1616786-26-5) + methyl 3-(dimethylamino)-4-hydroxybenzoate (316158-20-0)

Guidance literature:

methyl 3-(N,N-dimethylamino)benzoate-N-oxide; With trifluoroacetic anhydride; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - 0 ℃; for 0.25h; Overall yield = 38 %; Inert atmosphere;

DOI:10.1021/ol501813s

upstream raw materials:

3-(dimethylamino)benzoic acid methyl ester

Downstream raw materials:

methyl 2-hydroxy-3-(N,N-dimethylamino)benzoate

methyl 3-(dimethylamino)-4-hydroxybenzoate

methyl 3-(N,N-dimethylamino)-4-(trifluoromethanesulfonate)benzoate

methyl 3-(N,N-dimethylamino)-2-(trifluoromethanesulfonate)benzoate

Refernces