Multi-step reaction with 7 steps
1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethylmorpholine; / N,N-dimethyl-formamide / 0.5 h / 20 °C
1.2: 16 h / 0 - 28 °C
2.1: trifluoroacetic acid / dichloromethane / 50 h
3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 2 h / 17 - 28 °C
4.1: potassium acetate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / acetonitrile; water / 4 h / Reflux
5.1: potassium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / acetonitrile; water / 0.58 h / 80 °C / Inert atmosphere
6.1: Burgess Reagent / dichloromethane / 16 h / 17 - 28 °C / Inert atmosphere
7.1: formic acid / 0.25 h / 50 °C
With
N-ethylmorpholine;; formic acid; Burgess Reagent; potassium acetate; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II);
In
dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;