5-Bromo-3-methylpyridine-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 5-Bromo-3-methylpyridine-2-carboxylic acid methyl ester
• CAS No.: 213771-32-5
• Molecular Formula: C8H8BrNO2
• Molecular Weight: 230.061
• Hs Code.: 2933399090
• Mol file: 213771-32-5.mol

Synonyms:Methyl5-bromo-3-methylpyridine-2-carboxylate;

Chemical Property of 5-Bromo-3-methylpyridine-2-carboxylic acid methyl ester

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.548
• Boiling Point: 302.2 °C at 760 mmHg
• PKA: -0.17±0.10(Predicted)
• Flash Point: 136.6 °C
• PSA: 39.19000
• Density: 1.503 g/cm³
• LogP: 1.93910
• Storage Temp.: Room temperature.

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl5-Bromo-3-methylpicolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-3-methylpyridine-2-carboxylic acid methyl ester

There total 7 articles about 5-Bromo-3-methylpyridine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-bromo-3-methylpyridine-2-carboxylic acid (886365-43-1) → 5-bromo-3-methylpyridine-2-carboxylic acid methyl ester (213771-32-5)

Guidance literature:

With thionyl chloride; In methanol; for 6h; Reflux;

Reference yield: 94.0%

methanol (67-56-1) + 5-bromo-3-methylpyridine-2-carboxylic acid (886365-43-1) → 5-bromo-3-methylpyridine-2-carboxylic acid methyl ester (213771-32-5)

Guidance literature:

With sulfuric acid; In water; at 70 ℃;

DOI:10.1021/acsmedchemlett.1c00063

Reference yield: 83.0%

5-bromo-3-methylpyridine-2-carboxylic acid (886365-43-1) + methyl iodide (74-88-4) → 5-bromo-3-methylpyridine-2-carboxylic acid methyl ester (213771-32-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 0.666667h;

upstream raw materials:

methanol

2,5-dibromo-3-methylpyridine

carbon monoxide

5-bromo-3-methylpyridine-2-carbonitrile

Downstream raw materials:

5-bromo-3-bromomethylpyridine-2-carboxylic acid methyl ester

(S)-4-amino-N-(1-cyano-2-(4-(6-methyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)phenyl)ethyl)tetrahydro-2H-pyran-4-carboxamide

(S)-tert-butyl 1-(1-amino-3-(4-(6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)phenyl)-1-oxopropan-2-ylcarbamoyl)cyclohexylcarbamate

(S)-tert-butyl 1-(1-cyano-2-(4-(6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-yl)phenyl)ethylcarbamoyl)cyclohexylcarbamate

Refernces

• 1、 -. "HETEROCYCLIC GLP-1 AGONISTS". Page/Page column 336-337. . Retrieved 2022/02/15.
• 2、 -. "IMIDAZOPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER". Paragraph 00245. . Retrieved 2018/04/12.