Mannitol

Base Information

• Chemical Name: Mannitol
• CAS No.: 87-78-5
• Deprecated CAS: 123897-58-5,75398-80-0,85085-15-0,1081757-07-4,133-43-7,36413-61-3,5149-40-6,85085-15-0
• Molecular Formula: C₆H₁₄O₆
• Molecular Weight: 182.174
• Hs Code.: 29054300
• European Community (EC) Number: 200-711-8,201-770-2
• UNII: 3OWL53L36A
• DSSTox Substance ID: DTXSID1023235,DTXSID30858955
• Nikkaji Number: J2.369H
• Wikipedia: Mannitol
• Wikidata: Q407646
• NCI Thesaurus Code: C625
• RXCUI: 6628
• Metabolomics Workbench ID: 37414
• ChEMBL ID: CHEMBL689
• Mol file: 87-78-5.mol

Synonyms:(L)-Mannitol;Mannitol;Osmitrol;Osmofundin

Chemical Property of Mannitol

Chemical Property:

• Appearance/Colour: White fine powder
• Vapor Pressure: 7.22E-12mmHg at 25°C
• Melting Point: 166-168oC
• Refractive Index: 1.597
• Boiling Point: 494.9 °C at 760 mmHg
• PKA: pKa 13.50(H2O,t =18)(Approximate)
• Flash Point: 292.5 °C
• PSA: 121.38000
• Density: 1.596 g/cm³
• LogP: -3.58540
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: soluble
• XLogP3: -3.1
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 182.07903816
• Heavy Atom Count: 12
• Complexity: 105

Purity/Quality:

99% ^*data from raw suppliers

Mannitol Meets ACS Specifications GR ACS ^*data from reagent suppliers

Safty Information:

• Safety Statements: S24/25:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Biological Agents -> Monosaccharides and Derivatives
• Canonical SMILES: C(C(C(C(C(CO)O)O)O)O)O
• Isomeric SMILES: C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O
• Recent ClinicalTrials: Efficacy of Sodium Thiosulfate and Mannitol in Reducing Ototoxicity in Adult Patients Receiving Cisplatin Chemotherapy
• Recent EU Clinical Trials: Efficacy and Safety of mAnniTol in bowel preparation: assessment of adequacy and presence of Intestinal levelS of hydrogen and methane during elective colonoscopy aFter mAnnitol or standard split 2-liter polyethylene glycol solution plus asCorbaTe – a phase II/III, International, multicentre, randomized, parallel-group, endoscOpist-bliNded, dose-finding/non-inferiority study - SATISFACTION
• Recent NIPH Clinical Trials: A phase 1 study in patients with Fukuyama-type congenital muscular dystrophy
• Description: It can be used to lower intraocular pressure and in the postoperational period in ophthalomological procedures as well as during brain edema.
• Uses: Mannitol is a polyol (polyhydric alcohol) produced from hydrogena- tion from fructose that functions as a sweetener, humectant, and bulking agent. it has low hygroscopicity and poor oil solvency. it has 1.6 kcal/g. it is approximately 22% soluble in water and is approximately 72% as sweet as sugar, exhibiting a cool, sweet taste. it functions as a dusting agent with starch in chewing gum. it is used in sugarless candy, chewing gum, cereal, and pressed mints. Mannitol also known as wood mellow, is a kind of hexahydrin that can be used as a diuretic or sweetener.
• Clinical Use: Mannitol is the agent most commonly used as an osmotic diuretic. Sorbitol also can be used for similar reasons.Mannitol is administered intravenously in solutions of 5 to 50% at a rate of administration that is adjusted to maintain the urinary output at 30 to 50 ml/hour. Mannitol is filtered at the glomerulus and is poorly reabsorbed by the kidney tubule. The osmotic effect of mannitol in the tubule inhibits the reabsorption of water, and the rate of urine flow can be maintained. It also is used to reduce intracranial pressure by reducing cerebral intravascular volume.

Technology Process of Mannitol

There total 51 articles about Mannitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.2%

cellulose (9004-34-6) → propylene glycol (57-55-6,63625-56-9) + ethylene glycol (107-21-1) + isopropyl alcohol (67-63-0,8013-70-5) + sorbitol (50-70-4,69-65-8,87-78-5,133-43-7,488-44-8,488-45-9,608-66-2,643-01-6,643-03-8,5552-13-6,6706-59-8,24557-79-7,25878-23-3,26566-34-7,45007-61-2,60660-56-2,60660-57-3,60660-58-4,132747-27-4)

Guidance literature:

With water; at 220 ℃; for 0.5h; under 52505.3 Torr; Temperature; Pressure;

Reference yield: 33.6%

cellulose (9004-34-6) → propylene glycol (57-55-6,63625-56-9) + isopropyl alcohol (67-63-0,8013-70-5) + sorbitol (50-70-4,69-65-8,87-78-5,133-43-7,488-44-8,488-45-9,608-66-2,643-01-6,643-03-8,5552-13-6,6706-59-8,24557-79-7,25878-23-3,26566-34-7,45007-61-2,60660-56-2,60660-57-3,60660-58-4,132747-27-4)

Guidance literature:

With water; at 220 ℃; for 0.5h; under 45004.5 Torr; Temperature; Pressure;

Reference yield: 15.8%

cellulose (9004-34-6) → propylene glycol (57-55-6,63625-56-9) + sorbitol (50-70-4,69-65-8,87-78-5,133-43-7,488-44-8,488-45-9,608-66-2,643-01-6,643-03-8,5552-13-6,6706-59-8,24557-79-7,25878-23-3,26566-34-7,45007-61-2,60660-56-2,60660-57-3,60660-58-4,132747-27-4)

Guidance literature:

With hydrogen; In water; at 239.84 ℃; for 4h; under 30003 Torr;

DOI:10.1039/c2gc35685f

upstream raw materials:

D-sorbitol

D-glucose

D-talitol

L-altritol

Downstream raw materials:

1,2,3,4,5,6-hexakis(2-cyanoethoxy)hexane

1,3:2,4-bis(3,4-dimethylbenzylidene)sorbitol

2-methyloxane

methanol

Refernces

• 1、 Liu, Xiaohao,Liu, Xiaodong,Xu, Guangyue,Zhang, Ying,Wang, Chenguang,Lu, Qiang,Ma, Longlong. "Highly efficient catalytic conversion of cellulose into acetol over Ni-Sn supported on nanosilica and the mechanism study". . p. 5647 - 5656. Retrieved 2019/11/05.
• 2、 Lucas, Martin,Fabi?ovicová, Katarina,Claus, Peter. "Hydrothermally Stable Ruthenium–Zirconium–Tungsten Catalyst for Cellulose Hydrogenolysis to Polyols". . p. 612 - 618. Retrieved 2017/12/28.