Technology Process of Sertaconazole
There total 7 articles about Sertaconazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol;
With
tetra-(n-butyl)ammonium iodide; sodium hydroxide;
In
water; toluene;
at 50 ℃;
for 0.25h;
Inert atmosphere;
7-chloro-3-(chloromethyl)benzo[b]thiophene;
In
water; toluene;
at 50 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/jacs.0c03197
- Guidance literature:
-
With
sodium hydride;
Yield given. Multistep reaction;
1.) HMPT, RT; 2.) HMPT, 50 deg C, 1 h, 3.) HMPT, 0 deg C, 5 h;;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2.1: [Au2(μ-bis(diphenylphosphino)methane)2](OTf)2; sodium carbonate / acetonitrile / 15 h / Inert atmosphere; Irradiation; Glovebox
3.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere
3.2: 1 h / 20 °C / Inert atmosphere
4.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere; Cooling with ice
5.1: tetra-(n-butyl)ammonium iodide; sodium hydroxide / toluene; water / 0.25 h / 50 °C / Inert atmosphere
5.2: 4 h / 50 °C / Inert atmosphere
With
potassium tert-butylate; [Au2(μ-bis(diphenylphosphino)methane)2](OTf)2; tetra-(n-butyl)ammonium iodide; sodium carbonate; potassium carbonate; methanesulfonyl chloride; triethylamine; sodium hydroxide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jacs.0c03197