CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID

Base Information

• Chemical Name: CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID
• CAS No.: 74316-27-1
• Molecular Formula: C₅H₉NO₂
• Molecular Weight: 115.132
• Hs Code.: 2916399090
• Mol file: 74316-27-1.mol

Synonyms:CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID;3-aminocyclobutane-1-carboxylic acid;cis-3-Amino-cyclobutaneca...;rel-(1R,3R)-3-aMinocyclobutane-1-carboxylic acid

Chemical Property of CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0.00662mmHg at 25°C
• Refractive Index: 1.531
• Boiling Point: 251 °C at 760 mmHg
• Flash Point: 105.6 °C
• PSA: 63.32000
• Density: 1.267g/cm³
• LogP: 0.50860
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

cis-3-Aminocyclobutanecarboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Technology Process of CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID

There total 12 articles about CIS-3-AMINOCYCLOBUTANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methylester of 3-benzyloxycyclobutane-1-carboxylic acid (4934-98-9) → cis-3-aminocyclobutane-1-carboxylic acid (74316-27-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / H₂ / PtO₂ / methanol / 7 h

2: 88 percent / pyridine / 336 h

3: 1. NH₄Br, NH₃; 2. HCl / 1. 88 deg C, 16 h; 2. H₂O, 88 deg C, 20 h, heating

With pyridine; hydrogenchloride; ammonia; hydrogen; ammonium bromide; platinum(IV) oxide; In methanol;

Reference yield:

3-(benzyloxy)cyclobutane-1,1-dicarboxylic acid (84182-46-7) → cis-3-aminocyclobutane-1-carboxylic acid (74316-27-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 83 percent / 1. 150 deg C, 1 h, 4.0E₃ Pa; 2. 165 deg C, 2.5 h; 3. 180 deg C, 2.5 h

2: 81 percent / H₂SO₄ / CHCl₃ / 16 h / Heating

3: 85 percent / H₂ / PtO₂ / methanol / 7 h

4: 88 percent / pyridine / 336 h

5: 1. NH₄Br, NH₃; 2. HCl / 1. 88 deg C, 16 h; 2. H₂O, 88 deg C, 20 h, heating

With pyridine; hydrogenchloride; sulfuric acid; ammonia; hydrogen; ammonium bromide; platinum(IV) oxide; In methanol; chloroform;

Reference yield:

3-(benzyloxy)cyclobutane-1-carboxylic acid (4958-02-5) → cis-3-aminocyclobutane-1-carboxylic acid (74316-27-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 81 percent / H₂SO₄ / CHCl₃ / 16 h / Heating

2: 85 percent / H₂ / PtO₂ / methanol / 7 h

3: 88 percent / pyridine / 336 h

4: 1. NH₄Br, NH₃; 2. HCl / 1. 88 deg C, 16 h; 2. H₂O, 88 deg C, 20 h, heating

With pyridine; hydrogenchloride; sulfuric acid; ammonia; hydrogen; ammonium bromide; platinum(IV) oxide; In methanol; chloroform;

upstream raw materials:

methylester of 3-hydroxycyclobutane-1-carboxylic acid

methylester of 3-benzyloxycyclobutane-1-carboxylic acid

3-(benzyloxy)cyclobutane-1,1-dicarboxylic acid

3-(benzyloxy)cyclobutane-1-carboxylic acid

Refernces

• 1、 Safanda,Sobotka. "3-Aminocyclobutane-1-carboxylic acid: Synthesis and some neurochemical properties". . p. 2440 - 2447. Retrieved 2007/10/02.