2,2,3,3,4,4,5,5,6,6,7,7-dodecafluorooctanedioic acid (4-chlorophenyl)amide hydroxyamide

Base Information

• Chemical Name: 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluorooctanedioic acid (4-chlorophenyl)amide hydroxyamide
• CAS No.: 1308677-77-1
• Molecular Formula: C₁₄H₇ClF₁₂N₂O₃
• Molecular Weight: 514.655
• Mol file: 1308677-77-1.mol

Synonyms:2,2,3,3,4,4,5,5,6,6,7,7-dodecafluorooctanedioic acid (4-chlorophenyl)amide hydroxyamide

Chemical Property of 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluorooctanedioic acid (4-chlorophenyl)amide hydroxyamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluorooctanedioic acid (4-chlorophenyl)amide hydroxyamide

There total 6 articles about 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluorooctanedioic acid (4-chlorophenyl)amide hydroxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

→ 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluorooctanedioic acid (4-chlorophenyl)amide hydroxyamide (1308677-77-1)

Guidance literature:

Reference yield:

C21H12ClF12NO3 → 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluorooctanedioic acid (4-chlorophenyl)amide hydroxyamide (1308677-77-1)

Guidance literature:

With hydroxylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2011.11.041

Reference yield:

C21H13ClF12N2O3 → 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluorooctanedioic acid (4-chlorophenyl)amide hydroxyamide (1308677-77-1)

Guidance literature:

With hydroxylamine hydrochloride; triethylamine; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1016/j.bmcl.2017.02.050

upstream raw materials:

benzyl 7-chlorocarbonyl-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptanoate

2,2,3,3,4,4,5,5,6,6,7,7-dodecafluorooctanedioic acid

2,2,3,3,4,4,5,5,6,6,7,7-dodecafluorooctanedioyl dichloride

Refernces

• 1、 Henkes, Leonhard M.,Haus, Patricia,J?ger, Felix,Ludwig, Joachim,Meyer-Almes, Franz-Josef. "Synthesis and biochemical analysis of 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro- N-hydroxy-octanediamides as inhibitors of human histone deacetylases". experimental part. p. 985 - 995. Retrieved 2012/03/26.
• 2、 -. "Histone deacetylase (HDAC) inhibiting compounds and method of making same". Page/Page column 11. . Retrieved 2012/08/28.