Heptafluorobutyric anhydride

Base Information

• Chemical Name: Heptafluorobutyric anhydride
• CAS No.: 336-59-4
• Molecular Formula: C8F14O3
• Molecular Weight: 410.064
• Hs Code.: 29159080
• European Community (EC) Number: 206-410-8
• UNII: H5L67KPX9Z
• DSSTox Substance ID: DTXSID10861881
• Nikkaji Number: J193.783I
• Wikidata: Q27119860
• Metabolomics Workbench ID: 56301
• Mol file: 336-59-4.mol

Synonyms:heptafluorobutyric anhydride

Chemical Property of Heptafluorobutyric anhydride

Chemical Property:

• Appearance/Colour: clear colorless liquid
• Vapor Pressure: 1.5mmHg at 25°C
• Melting Point: ?43 °C(lit.)
• Refractive Index: n20/D 1.287(lit.)
• Boiling Point: 106.7 °C at 760 mmHg
• Flash Point: 18.9 °C
• PSA: 43.37000
• Density: 1.724 g/cm³
• LogP: 3.72200
• Storage Temp.: Room temp
• Sensitive.: Hygroscopic
• Solubility.: Miscible with halogenated solvents. Immiscible with polar solven
• Water Solubility.: REACTS
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 17
• Rotatable Bond Count: 6
• Exact Mass: 409.9623881
• Heavy Atom Count: 25
• Complexity: 493

Purity/Quality:

99% ^*data from raw suppliers

Heptafluorobutyric Anhydride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(=O)(C(C(C(F)(F)F)(F)F)(F)F)OC(=O)C(C(C(F)(F)F)(F)F)(F)F
• Uses: As a GC derivatizing agent, Heptafluorobutyric anhydride is used to prepare volatile derivatives of amino acids and other biologically active compounds. Heptafluorobutyric anhydride (HFAA) is frequently used as an acylating agent for the derivatization of primary and secondary amines (Walle and Ehrsson, 1971). Commercially available Heptafluorobutyric anhydride may afford low yields of the derivative due to the presence of Heptafluorobutyric acid (Moodie et al., 1985). This contaminant may be removed by ditillation over phosphorus pentoxide (Walle and Ehrsson, 1970). HFAA is used to increase volatility of an analyte, and to introduce fluorine atoms for better detection limits in gas chromatography applications. suzuki reaction Heptafluorobutyric anhydride is used as a derivatization reagent for gas chromatography - mass mass spectrometry analysis of the stereoisomer content of synthetic peptides. It is a GC derivatizing agent used to prepare volatile derivatives of amino acids and other biologically active compounds.

Technology Process of Heptafluorobutyric anhydride

There total 10 articles about Heptafluorobutyric anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

heptafluorobutyric Acid (375-22-4) → perfluoropropylene (116-15-4,13429-24-8,25120-07-4,6792-31-0) + perfluorobutyryl fluoride (335-42-2) + heptafluorobutyric anhydride (336-59-4)

Guidance literature:

Pyrolyse von Lithium-, Calcium-, Strontium-, Blei- und Aluminium-Salz_.Pyrolysis;

DOI:10.1021/ja01114a040

Reference yield:

silver heptafluorobutyrate (3794-64-7) → heptafluorobutyric anhydride (336-59-4)

Guidance literature:

With sulfur; at 255 ℃;

DOI:10.1021/ja01109a029

Reference yield:

heptafluorobutyric Acid (375-22-4) → heptafluorobutyric anhydride (336-59-4)

Guidance literature:

With phosphorus pentoxide;

DOI:10.1039/jr9500002789 DOI:10.1021/jo01109a612

upstream raw materials:

heptafluorobutyric Acid

silver heptafluorobutyrate

heptafluorobutyryl chloride

Trifluoromethylsulfenyl chloride

Downstream raw materials:

heptafluoro-butyric acid biphenyl-2-ylamide

heptafluoro-butyric acid-(4-nitro-anilide)

2,2,3,3,4,4,4-heptafluoro-N-(2-phenylethyl)butanamide

N-heptafluorobutyryl-1-phenylethylamine

Refernces

• 1、 -. "Hydroxy protection groups". . . Retrieved 2008/06/13.
• 2、 Aleinikov, S. F.,Krutikov, V. I.,Lavrent'ev, A. N.,Bakhmutov, Yu. L.,Andreeva, R. K.. "REACTIONS OF PHOSPHITE ESTERS WITH THE ANHYDRIDES OF PERFLUORINATED CARBOXYLIC ACIDS: CALORIMETRY AND IR SPECTRA". . p. 1785 - 1788. Retrieved 2007/10/02.