Technology Process of 2-[4-(3-benzyloxy-propoxy)-benzoyl]-benzoic acid tert-butyl ester
There total 7 articles about 2-[4-(3-benzyloxy-propoxy)-benzoyl]-benzoic acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 71 percent / AlCl3 / CH2Cl2 / 16 h / Heating
2: aq. HBr; glacial AcOH / 26 h / 115 - 125 °C
3: 2.94 g / H2SO4 / Heating
4: 88 percent / DIAD; Ph3P / CH2Cl2 / 3 h / 0 - 20 °C
5: aq. LiOH / tetrahydrofuran; methanol / 4 h
6: 3.06 g / MgSO4; H2SO4 / CHCl3
With
lithium hydroxide; aluminium trichloride; di-isopropyl azodicarboxylate; sulfuric acid; hydrogen bromide; magnesium sulfate; acetic acid; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; chloroform;
1: Friedel-Crafts reaction / 4: Mitsunobu reaction;
DOI:10.1021/jm0305117
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 2.94 g / H2SO4 / Heating
2: 88 percent / DIAD; Ph3P / CH2Cl2 / 3 h / 0 - 20 °C
3: aq. LiOH / tetrahydrofuran; methanol / 4 h
4: 3.06 g / MgSO4; H2SO4 / CHCl3
With
lithium hydroxide; di-isopropyl azodicarboxylate; sulfuric acid; magnesium sulfate; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; chloroform;
2: Mitsunobu reaction;
DOI:10.1021/jm0305117
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 88 percent / DIAD; Ph3P / CH2Cl2 / 3 h / 0 - 20 °C
2: aq. LiOH / tetrahydrofuran; methanol / 4 h
3: 3.06 g / MgSO4; H2SO4 / CHCl3
With
lithium hydroxide; di-isopropyl azodicarboxylate; sulfuric acid; magnesium sulfate; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; chloroform;
1: Mitsunobu reaction;
DOI:10.1021/jm0305117