(5R,8S,10R)-8-methoxycarbonylergoline

Base Information

• Chemical Name: (5R,8S,10R)-8-methoxycarbonylergoline
• CAS No.: 86891-09-0
• Molecular Formula: C₁₆H₁₈N₂O₂
• Molecular Weight: 270.331
• Mol file: 86891-09-0.mol

Synonyms:(5R,8S,10R)-8-methoxycarbonylergoline

Chemical Property of (5R,8S,10R)-8-methoxycarbonylergoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5R,8S,10R)-8-methoxycarbonylergoline

There total 14 articles about (5R,8S,10R)-8-methoxycarbonylergoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ #rac-ergoline-8β-carboxylic acid methyl ester (30341-92-5,86891-09-0)

Guidance literature:

With hydrogenchloride; amalgamated zinc; acetic acid; Behandeln des Reaktionsprodukts mit Methanol und H₂SO₄, Erhitzen des hierbei erhaltenen Produkts mit Natrium und Butan-1-ol und Behandeln des Reaktionsprodukts mit methanol.HCl;

DOI:10.1093/chromsci/40.9.509

Reference yield:

4,5-dihydro-indolo[4,3-fg]quinoline-9-carboxylic acid ethyl ester (109698-20-6) → #rac-ergoline-8β-carboxylic acid methyl ester (30341-92-5,86891-09-0)

Guidance literature:

With ethanol; sodium; anschliessend mit methanol.HCl;

DOI:10.1093/chromsci/41.9.480

Reference yield:

4-acetyl-4,5-dihydro-indolo[4,3-fg]quinoline-9-carbonitrile (109601-99-2) → #rac-ergoline-8β-carboxylic acid methyl ester (30341-92-5,86891-09-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous H₂SO₄; NH₄Cl

2: sodium; ethanol / anschliessend mit methanol.HCl

With ethanol; sulfuric acid; sodium; ammonium chloride;

DOI:10.1093/chromsci/41.9.480

upstream raw materials:

methanol

4,5-dihydro-indolo[4,3-fg]quinoline-9-carboxylic acid ethyl ester

4-acetyl-4,5-dihydro-indolo[4,3-fg]quinoline-9-carbonitrile

Downstream raw materials:

rac-6-methyl-5α-ergoline-8β-carboxylic acid methyl ester

rac-6-methyl-5α-ergoline-8α-carboxylic acid methyl ester

rac-6-ethyl-ergoline-8β-carboxylic acid methyl ester

rac-6-propyl-ergoline-8β-carboxylic acid methyl ester