1,2-Diformylhydrazine

Base Information

• Chemical Name: 1,2-Diformylhydrazine
• CAS No.: 628-36-4
• Deprecated CAS: 1025436-11-6
• Molecular Formula: C2H4N2O2
• Molecular Weight: 88.066
• Hs Code.: 29280000
• European Community (EC) Number: 211-040-5
• NSC Number: 54729
• DSSTox Substance ID: DTXSID8020468
• Nikkaji Number: J69.828H
• Wikipedia: 1,2-Diformylhydrazine
• Wikidata: Q19903951
• ChEMBL ID: CHEMBL3185965
• Mol file: 628-36-4.mol

Synonyms:1,2-diformylhydrazine

Chemical Property of 1,2-Diformylhydrazine

Chemical Property:

• Appearance/Colour: WHITE
• Vapor Pressure: 3.28mmHg at 25°C
• Melting Point: 155-160 ºC
• Refractive Index: 1.425
• Boiling Point: 153.7ºC at 760 mmHg
• PKA: 11.92±0.23(Predicted)
• Flash Point: 81.6 ºC
• PSA: 65.18000
• Density: 1.193 g/cm³
• LogP: 0.07400
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 88.027277375
• Heavy Atom Count: 6
• Complexity: 45.5

Purity/Quality:

99% ^*data from raw suppliers

1,2-Diformylhydrazine ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(=O)NNC=O
• Uses: 1,2-Diformylhydrazine as a bidentate ligand forms 1:1 metal to ligand complexes with transition metals Mn, Zn and Ni. It combines with iron (II) and iron(III) in alkaline conditions to a complex of an intense red-purple color making it a useful reagent in spectrophotometric analysis of iron(II) and iron(III). It was observed that mice were more likely to develop lung tumor when administered 1,2-Diformylhydrazine as a 2% solution.

Technology Process of 1,2-Diformylhydrazine

There total 16 articles about 1,2-Diformylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

formic acid ethyl ester (109-94-4) → diformylhydrazine (628-36-4)

Guidance literature:

With hydrazine hydrate; at 0 ℃; for 48h;

DOI:10.1016/j.mencom.2015.09.029

Reference yield: 91.0%

formic acid (64-18-6) → diformylhydrazine (628-36-4)

Guidance literature:

With hydrazine; In di-isopropyl ether; Heating;

Reference yield: 65.0%

formamide (77287-34-4,77287-35-5,60100-09-6) → diformylhydrazine (628-36-4)

Guidance literature:

With hydrazine hydrate; at 90 ℃;

DOI:10.1002/asia.201100769

upstream raw materials:

formic acid

sodium formate

formamide

formic acid ethyl ester

Downstream raw materials:

(3-oxo-5-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-(5-oxo-3-phenyl-1,5-dihydro-pyrazol-4-ylidene)-methane

1-(2,5-dichlorophenyl)-1H-1,2,3,4-tetrazole

4-(4-methylphenyl)-4H-1,2,4-triazole

4-o-tolyl-1,2,4-triazole

Refernces

• 1、 -. "Preparation method of hexahydropyridazine dihydrochloride". Paragraph 0028-0031; 0036-0038; 0041-0043; 0046-0048. . Retrieved 2019/12/02.
• 2、 Holmberg, Rebecca J.,Kay, Marika,Korobkov, Ilia,Kadantsev, Eugene,Boyd, Peter G.,Aharen, Tomoko,Desgreniers, Serge,Woo, Tom K.,Murugesu, Muralee. "An unprecedented CoII cuboctahedron as the secondary building unit in a Co-based metal-organic framework". supporting information. p. 5333 - 5335. Retrieved 2014/05/06.