p-fluorobenzylamine formamide

Base Information

• Chemical Name: p-fluorobenzylamine formamide
• CAS No.: 84174-25-4
• Molecular Formula: C₈H₈FNO
• Molecular Weight: 153.156
• Mol file: 84174-25-4.mol

Synonyms:p-fluorobenzylamine formamide

Chemical Property of p-fluorobenzylamine formamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of p-fluorobenzylamine formamide

There total 10 articles about p-fluorobenzylamine formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

carbon dioxide (124-38-9,18923-20-1) + para-fluorobenzylamine (140-75-0) → p-fluorobenzylamine formamide (84174-25-4)

Guidance literature:

With Au-TiO₂; hydrogen; In N,N-dimethyl acetamide; at 120 ℃; for 5h;

DOI:10.1002/cctc.201700726

Reference yield: 89.0%

formic acid (64-18-6) + para-fluorobenzylamine (140-75-0) → p-fluorobenzylamine formamide (84174-25-4)

Guidance literature:

With C₅H₉CrMo₆O₂₄^(6-)*3H⁽¹⁺⁾*3C₁₆H₃₆N⁽¹⁺⁾; sodium sulfite; In 1,4-dioxane; at 80 ℃; for 4h; chemoselective reaction; Green chemistry;

DOI:10.1039/d0dt03300f

Reference yield: 88.0%

para-fluorobenzylamine (140-75-0) + formic acid ethyl ester (109-94-4) → p-fluorobenzylamine formamide (84174-25-4)

Guidance literature:

at 0 - 20 ℃; for 4h;

DOI:10.1021/jm960070+

upstream raw materials:

para-fluorobenzylamine

formic acid ethyl ester

carbon monoxide

methanol

Downstream raw materials:

4-fluorobenzyl isocyanide

methyl 2-isocyano-2-(4-fluorophenyl)acetate

3-(4-fluorobenzyl)-1-methylimidazolidine-2,4-dione

1,1,1-trifluoro-3-((4-fluorobenzyl)amino)-3-oxo-2-phenylpropan-2-yl acetate

Refernces

• 1、 Kumar, Arun,Kumar, Yashwant,Mahajan, Dinesh,Sharma, Nidhi,Sharma, Pankaj. "Catalyst freeN-formylation of aromatic and aliphatic amines exploiting reductive formylation of CO2using NaBH4". . p. 25777 - 25787. Retrieved 2021/08/05.
• 2、 Borase, Bhushan B.,Godbole, Himanshu M.,Singh, Girij P.,Upadhyay, Pritesh R.,Trivedi, Anurag,Bhat, Varadaraj,Shenoy, Gautham G.. "Application of Ugi three component reaction for the synthesis of quinapril hydrochloride". supporting information. p. 48 - 55. Retrieved 2019/11/19.