C₂₆H₂₄N₂O₉

Base Information

• Chemical Name: C₂₆H₂₄N₂O₉
• CAS No.: 849342-80-9
• Molecular Formula: C₂₆H₂₄N₂O₉
• Molecular Weight: 508.485
• Mol file: 849342-80-9.mol

Synonyms:C₂₆H₂₄N₂O₉

Chemical Property of C₂₆H₂₄N₂O₉

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of C₂₆H₂₄N₂O₉

There total 2 articles about C₂₆H₂₄N₂O₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

thymin (65-71-4,28806-14-6,691841-57-3) + 1,2-di-O-acetyl-3,5-di-O-benzoyl-β-L-ribofuranose (173009-66-0) → C26H24N2O9 (849342-80-9)

Guidance literature:

thymin; With 1,1,1,3,3,3-hexamethyl-disilazane; for 3h; Heating;

1,2-di-O-acetyl-3,5-di-O-benzoyl-β-L-ribofuranose; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 20 ℃;

DOI:10.1016/j.bmc.2004.12.011

Reference yield:

1,2-di-O-isopropylidene-3,5-di-O-benzoyl-α-L-ribofuranose (171721-12-3) → C26H24N2O9 (849342-80-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 99 percent / acetic acid; sulfuric acid / 16 h / 20 °C

2.1: 1,1,1,3,3,3-hexamethyldisilazane / 3 h / Heating

2.2: 73 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 20 °C

With sulfuric acid; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; 2.2: Vorbrueggen condensation;

DOI:10.1016/j.bmc.2004.12.011

Reference yield: 96.0%

C26H24N2O9 (849342-80-9) → 1-(β-L-ribofuranosyl)thymine (26879-47-0,642082-80-2)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃;

DOI:10.1016/j.bmc.2004.12.011

upstream raw materials:

thymin

1,2-di-O-acetyl-3,5-di-O-benzoyl-β-L-ribofuranose

1,2-di-O-isopropylidene-3,5-di-O-benzoyl-α-L-ribofuranose

Downstream raw materials:

1-(β-L-ribofuranosyl)thymine

L-2,2'-anhydro-5-methyluridine

1-((2S,3S,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Refernces