methyl 2,2-difluoro-2-phenylacetate

Base Information

• Chemical Name: methyl 2,2-difluoro-2-phenylacetate
• CAS No.: 56071-96-6
• Molecular Formula: C₉H₈F₂O₂
• Molecular Weight: 186.158
• Mol file: 56071-96-6.mol

Synonyms:methyl 2,2-difluoro-2-phenylacetate

Chemical Property of methyl 2,2-difluoro-2-phenylacetate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 2,2-difluoro-2-phenylacetate

There total 10 articles about methyl 2,2-difluoro-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methyl 2-oxo-2-phenylacetate (15206-55-0) → methyl 2,2-difluoro-2-phenylacetate (56071-96-6)

Guidance literature:

With diethylamino-sulfur trifluoride; for 4h;

DOI:10.1039/c39940001355

Reference yield: 81.0%

Methyl phenyldiazoacetate (22979-35-7) → methyl 2,2-difluoro-2-phenylacetate (56071-96-6)

Guidance literature:

With 4-(difluoroiodo)toluene; chlorobenzene; at 110 ℃; for 0.166667h; Reagent/catalyst;

DOI:10.1002/ejoc.201600773

Reference yield: 80.0%

iodobenzene (591-50-4) + methyl difluoroiodoacetate (109872-87-9) → methyl 2,2-difluoro-2-phenylacetate (56071-96-6)

Guidance literature:

With copper; In dimethyl sulfoxide; for 4h; Ambient temperature;

DOI:10.1016/S0040-4039(00)85409-X

upstream raw materials:

methyl 2-oxo-2-phenylacetate

iodobenzene

methyl difluoroiodoacetate

carbon dioxide

Downstream raw materials:

2,2,4,4-Tetrafluoro-N,N-diisopropyl-3-oxo-4-phenyl-butyramide

4,4-Difluoro-3-oxo-2,4-diphenyl-butyronitrile

2,2-difluoro-2-phenylethan-1-ol

2,2-Difluoro-2-phenylacetic acid

Refernces

• 1、 Sinclair, Geoffrey S.,Tran, Richard,Tao, Jason,Hopkins, W. Scott,Murphy, Graham K.. "Borosilicate Activation of (Difluoroiodo)toluene in the gem-Difluorination of Phenyldiazoacetate Derivatives". supporting information. p. 4603 - 4606. Retrieved 2016/09/28.
• 2、 Ilayaraja,Manivel,Velayutham,Noel. "The effect of substituents and operating conditions on the electrochemical fluorination of alkyl phenylacetates in Et3N·4HF medium". . p. 185 - 192. Retrieved 2008/09/17.