(+)-Neomenthol

Base Information Edit

Chemical Name:(+)-Neomenthol
CAS No.:89-78-1
Deprecated CAS:491-01-0
Molecular Formula:C10H20O
Molecular Weight:156.268
Hs Code.:2906.11
European Community (EC) Number:201-939-0,222-824-1,218-691-4,207-723-2
UNII:89S3KO7RR9,42RE7MA7PA
DSSTox Substance ID:DTXSID9044326,DTXSID20883998
Nikkaji Number:J215.948A
Wikidata:Q27089418
Metabolomics Workbench ID:28093
ChEMBL ID:CHEMBL1907991
Mol file:89-78-1.mol

Synonyms:(+)-Neomenthol;2216-52-6;d-Neomenthol;dl-Neomenthol;(1S,2S,5R)-2-Isopropyl-5-methylcyclohexanol;3623-51-6;Neomenthol, (+)-;Neo-Menthol;Neomenthol, D-;Neomenthol;(+-)-Neomenthol;Neomenthol, (+/-)-;Menthol, (1R,3S,4S)-(+)-;UNII-42RE7MA7PA;42RE7MA7PA;UNII-89S3KO7RR9;(1S,2S,5R)-5-methyl-2-propan-2-ylcyclohexan-1-ol;(1S,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexan-1-ol;89S3KO7RR9;CHEBI:15402;Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1R,2R,5S)-rel-;EINECS 207-723-2;EINECS 218-691-4;EINECS 222-824-1;Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1S,2S,5R)-;2-Isopropyl-5-methylcyclohexanol stereoisomer;Hexahydrothymol;(1S,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexanol;rac-Menthol;Menthol, racemic;D - menthol;(1)-Neomenthol;p-Menthan-3-ol;5-Methyl-2-(1-methylethyl)cyclohexanol, (1S(1alpha,2alpha,5beta))-;Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1S-(1alpha,2alpha,5beta))-;()-Neomenthol;Racementhol [BAN:INN];(1R,2S,5R)-Menthol;dextro-menthol;dl-neo-menthol;(1S,2S,5R)-(+)-Neomenthol;89-78-1;MENTHOL, trans-1,3-cis-1,4-(+-)-;(+)-Neomenthol-d4;bmse000498;(1S,2S,5R)-Menthol;D-NEOMENTHOL [FHFI];Ciclohexanol, 5-metil-2-(1-metiletil)-, (1r, 2s, 5r)-rel-;SCHEMBL260049;CHEMBL1907991;Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1.alpha.,2.beta.,5.alpha.)-;Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1alpha,2alpha,5beta)-(+/-)-;DTXSID9044326;FEMA 2666;NOOLISFMXDJSKH-UTLUCORTSA-;DTXSID20883998;(1S,2S,5R)-NEOMENTHOL;Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1-alpha,2-alpha,5-beta)-(+-)-;CYCLOHEXANOL, 5-METHYL-2-(1-METHYLETHYL)-, (1S-(1.ALPHA.,2.ALPHA.,5.BETA.))-;Cyclohexanol, 5-methyl-2-(1-methylethyl)-, [1S-(1.alpha.,2.alpha.,5.beta.)]-;( .PLUS/MINUS.) - neomenthol;491-01-0;CAA21652;Menthol, (1R,3S,4S)-()-;MFCD00062980;AKOS015895932;LMPR0102090003;BS-50681;N0626;(1S,2S,5R)-(+)-Neomenthol, >=95%;C00553;D91752;(1S,2R,5S)-5-methyl-2-isopropyl-cyclohexanol;J-014560;J-500420;MENTHOL, TRANS-1,3,TRANS-1,4-(+/-)-;Q27089418;Cyclohexanol,5-methyl-2-(1-methylethyl)-,(1S,2S,5R)-;Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1-alpha,2-alpha,5-beta)-(+)-;CYCLOHEXANOL, 5-METHYL-2-(1-METHYLETHYL)-, (1.ALPHA.,2.ALPHA.,5.BETA.)-(+/-)-;Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1.alpha.,2.alpha.,5.beta.)-(.+-.)-;Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1.alpha.,2.alpha.,5.beta.)-(.+.)-

Suppliers and Price of (+)-Neomenthol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
DL-Menthol
1g
$ 265.00

TCI Chemical
(+/-)-Menthol >98.0%(GC)
500mL
$ 137.00

TCI Chemical
(+/-)-Menthol >98.0%(GC)
100mL
$ 38.00

TCI Chemical
(+/-)-Menthol >98.0%(GC)
25mL
$ 16.00

Sigma-Aldrich
DL-Menthol DL-Menthol for synthesis. CAS 89-78-1, molar mass 156.27 g/mol., for synthesis
8184520100
$ 40.00

Sigma-Aldrich
Menthol 99%
5 g
$ 39.20

Sigma-Aldrich
DL-Menthol ≥95%,FCC,FG
1 SAMPLE-K
$ 50.00

Sigma-Aldrich
DL-Menthol ≥95%, FCC, FG
sample-k
$ 50.00

Sigma-Aldrich
(?)-Menthol analytical standard
100 g
$ 52.70

Sigma-Aldrich
(?)-Menthol analytical standard
1 g
$ 22.90

Total 249 raw suppliers

Chemical Property of (+)-Neomenthol Edit

Chemical Property:

Appearance/Colour:colorless need-like crystals
Vapor Pressure:0.8 mm Hg ( 20 °C)
Melting Point:32-36 °C
Refractive Index:1.4615
Boiling Point:215.383 °C at 760 mmHg
PKA:15.30±0.60(Predicted)
Flash Point:93.333 °C
PSA：20.23000
Density:0.89 g/cm³
LogP:2.43950
Storage Temp.:Store below +30°C.
Solubility.:456mg/l
Water Solubility.:insoluble
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:156.151415257
Heavy Atom Count:11
Complexity:120

Purity/Quality:

99.5% ^*data from raw suppliers

DL-Menthol ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn, Xi
Hazard Codes:Xn,Xi
Statements: 37/38-41-36/37/38
Safety Statements: 36/37/39-24/25-36-26-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Chemical Classes:Biological Agents -> Plant Oils and Extracts
Canonical SMILES:CC1CCC(C(C1)O)C(C)C
Isomeric SMILES:C[C@@H]1CC[C@H]([C@H](C1)O)C(C)C
Uses It is mainly used in medicine, toothpaste, toothpaste and mouthwash with its cool taste being able to enhance the smell of peppermint oil, having effect of refreshing the brain as well as disinfection effects. It can also be used as spices to be applied to the colognes. Application of appropriate amount of low-grade soap and detergent fragrance such as roses, geraniol, lavender and fragrant has effects of enhancing the tone and aroma. It can also be applied to food flavors and flavor for wine and tobacco. In medicine, it can be applied to the cooling oil, painkillers, etc., it can also be used for making toothpaste, toothpowder, candy, beverages, spices and so on. How to use: it can be used for formulating the food flavor in the food flavor plant; or also be directly added or dissolved in alcohol to be added to the food flavoring. Storage requirements: placed in a cool place, sealed for storage. Avoid wind and rain. A chemical which triggers cold-sensitive TRPM8 receptors in the skin neurons in vitro. In liqueurs, confectionery, perfumery, cigarettes, cough drops, and nasal inhalers. DL-Menthol may be used as an extraction solvent for the determination of parabens in food products, cosmetics and pharmaceuticals using liquid-liquid microextraction with high performance liquid chromatography-diode array detection (HPLC-DAD). It may also be used for the preparation of hydrophobic deep eutectic solvent (DES) in the extraction and determination of methylparaben, propylparaben, and butylparaben from cosmetics samples using syringe-to-syringe dispersive magnetic nanofluid microextraction procedure (SS-DMNF-ME) with high-performance liquid chromatography technique (HPLC).
Description (±)-Menthol is a racemic mixture of the monoterpene alcohols (–)-menthol and (+)-menthol , which have been found in Cannabis. (–)-Menthol is more common than (+)-menthol in nature and exhibits analgesic, antibacterial, and anticancer properties, as well as inhibits cholinesterase. (+)-Menthol inhibits the growth of F. verticillioides (MIC = 1.5 mM) but, unlike (–)-menthol, does not exhibit analgesic, antibacterial, anticancer, or cholinesterase inhibitory activities. Menthol has a mint-like odor and a fresh, cooling taste. It may be prepared by hydrogenation of thymol.
Physical properties Appearance: colorless or white acicular prismatic crystals or white crystalline powder. Solubility: easily dissolved in ethanol, chloroform, ether, liquid paraffin, or volatile oil and soluble in water. Odor: a cool, refreshing, and pleasant mint aroma, sweet odor, and taste cool early after burning. Boiling point: 212?°C. Melting point: 41–43?°C. Specific optical rotation: ?49 to ?50°.
Indications For external application, it is applied locally and often used to relieve pain and itching. A nasal drip is used in the head cold. Inhalation or spray is used for sore throat. Oral administration can promote digestion.
Clinical Use It can be clinically used to assist anesthesia, postoperative analgesia, intercostal nerve block, trigeminal nerve block, occipital nerve block, and so on. When applied locally, it can promote blood circulation, diminish inflammation, relieve itching, relieve pain, relieve edema, and so on.

Technology Process of (+)-Neomenthol

There total 152 articles about (+)-Neomenthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.58%