4-aminobenzamidopyridine

Base Information

• Chemical Name: 4-aminobenzamidopyridine
• CAS No.: 7467-42-7
• Molecular Formula: C12H13Cl2N3O
• Molecular Weight: 213.239
• Hs Code.: 2933399090
• Mol file: 7467-42-7.mol

Synonyms:4-amino-benzoic acid-[2]pyridylamide;2-(p-Aminobenzamido)pyridine;Benzamide,p-amino-N-2-pyridinyl;4-Amino-benzoesaeure-[2]pyridylamid;Benzamide,4-amino-N-2-pyridinyl;4-Amino-N-(2-pyridyl)benzamide;4-amino-N-pyridin-2-yl-benzamide;4-amino-N-pyridine-2-ylbenzamide;4-Aminobenzamidopyridine;Pyridine,2-(p-aminobenzamido);2-(p-Amino-benzamido)-pyridin;

Chemical Property of 4-aminobenzamidopyridine

Chemical Property:

• Vapor Pressure: 7.29E-05mmHg at 25°C
• Boiling Point: 342.9°C at 760 mmHg
• Flash Point: 161.2°C
• PSA: 68.01000
• LogP: 2.57030
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Amino-N-pyridin-2-ylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-aminobenzamidopyridine

There total 5 articles about 4-aminobenzamidopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-nitro-N-pyridine-2-yl-benzamide (7498-40-0) → 4-amino-N-(pyridin-2-yl)benzamide (7467-42-7)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In 1,4-dioxane; methanol; for 24h; under 760.051 Torr;

Reference yield: 89.9%

→ 4-amino-N-(pyridin-2-yl)benzamide (7467-42-7)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 85 ℃; for 1h;

Reference yield: 75.49%

2-aminopyridine (504-29-0) + 4-(N-tert-butoxycarbonyl)aminobenzoic acid (66493-39-8) → 4-amino-N-(pyridin-2-yl)benzamide (7467-42-7)

Guidance literature:

2-aminopyridine; 4-(N-tert-butoxycarbonyl)aminobenzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 24h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

upstream raw materials:

4-nitro-N-pyridine-2-yl-benzamide

2-aminopyridine

4-nitro-benzoic acid

4-(N-tert-butoxycarbonyl)aminobenzoic acid

Downstream raw materials:

N-(pyridine-2-yl)-4-dodecanamido-benzamide

N-(pyridin-2-yl)-4-stearamidobenzamide

4-((3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)amino)-N-(pyridin-2-yl)benzamide

Refernces

• 1、 -. "S-triazine compounds as well as preparation method and application thereof". Paragraph 0091; 0094; 0098-0099. . Retrieved 2020/05/05.
• 2、 -. "AMINONAPTHOQUINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITION FOR BLOCKING UBIQUITINATION-PROTEASOME SYSTEM IN DISEASES". Paragraph 00182. . Retrieved 2017/02/09.