trimethylsilyl methioninate

Base Information

• Chemical Name: trimethylsilyl methioninate
• CAS No.: 5269-64-7
• Molecular Formula: C₈H₁₉NO₂SSi
• Molecular Weight: 221.396
• Mol file: 5269-64-7.mol

Synonyms:O-(Trimethylsilyl)methionine

Chemical Property of trimethylsilyl methioninate

Chemical Property:

• Vapor Pressure: 0.0148mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trimethylsilyl methioninate

There total 2 articles about trimethylsilyl methioninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloro-trimethyl-silane (75-77-4) + L-methionine (63-68-3,26062-47-5,58576-49-1) → O-(Trimethylsilyl)methionine (5269-64-7)

Guidance literature:

In chloroform; acetonitrile; for 2h; Heating;

DOI:10.1021/jo00346a031

Reference yield:

L-methionine (63-68-3,26062-47-5,58576-49-1) + N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide (24589-78-4) → O-(Trimethylsilyl)methionine (5269-64-7)

Guidance literature:

In dichloromethane; for 1h; Heating;

DOI:10.1080/00304949809355277

Reference yield:

O-(Trimethylsilyl)methionine (5269-64-7) → N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine (71989-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 72 h / Ambient temperature

2: MeOH / CH₂Cl₂ / 0.5 h / Ambient temperature

With methanol; In dichloromethane;

DOI:10.1080/00304949809355277

upstream raw materials:

chloro-trimethyl-silane

L-methionine

N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide

Downstream raw materials:

N-trityl-L-methionine

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methionine

Refernces

• 1、 Barlos, Kleomenis,Papaioannou, Dionysios,Theodoropoulos, Dimitrios. "Efficient "One-Pot" Synthesis of N-Trityl Amino Acids". . p. 1324 - 1326. Retrieved 2007/10/02.