2,2'-dimethylbenzhydrylamine

Base Information

• Chemical Name: 2,2'-dimethylbenzhydrylamine
• CAS No.: 246853-44-1
• Molecular Formula: C₁₅H₁₇N
• Molecular Weight: 211.307
• Mol file: 246853-44-1.mol

Synonyms:2,2'-dimethylbenzhydrylamine

Chemical Property of 2,2'-dimethylbenzhydrylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2'-dimethylbenzhydrylamine

There total 8 articles about 2,2'-dimethylbenzhydrylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ortho-tolylmagnesium bromide (932-31-0) + 2-Methylbenzonitrile (529-19-1) → 2,2'-dimethylbenzhydrylamine (246853-44-1)

Guidance literature:

ortho-tolylmagnesium bromide; 2-Methylbenzonitrile; In tetrahydrofuran; for 24h; Inert atmosphere; Reflux;

With lithium aluminium tetrahydride; In tetrahydrofuran; at 25 ℃; Inert atmosphere; Reflux;

DOI:10.1021/ol802431v

Reference yield: 66.0%

bis-o-tolyl N-hydroxyoxime (108714-78-9) → 2,2'-dimethylbenzhydrylamine (246853-44-1)

Guidance literature:

With ammonia; sodium; In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.1021/jm990171i

Reference yield:

di-o-tolylmethyl-carbamic acid phenyl ester → 2,2'-dimethylbenzhydrylamine (246853-44-1)

Guidance literature:

With lithium hydroxide; In water; acetonitrile; at 50 ℃; for 3h;

DOI:10.1021/ol060939a

upstream raw materials:

bis(2-methylphenyl)methanimine

bis-o-tolyl N-hydroxyoxime

2-methylphenyl bromide

bis(2-methylphenyl)methanol

Downstream raw materials:

N-benzylidene-bis(2-methylphenyl)methylamine

Refernces

• 1、 Zhang, Yu,Lu, Zhenjie,Desai, Aman,Wulff, William D.. "Mapping the active site in a chemzyme: Diversity in the N-substituent in the catalytic asymmetric aziridination of imines". supporting information; experimental part. p. 5429 - 5432. Retrieved 2009/06/20.
• 2、 Liu, Gang,Kozmina, Natasha S.,Winn, Martin,Von Geldern, Thomas W.,Chiou, William J.,Dixon, Douglas B.,Nguyen, Bach,Marsh, Kennan C.,Opgenorth, Terry J.. "Design, synthesis, and activity of a series of pyrrolidine-3-carboxylic acid-based, highly specific, orally active ET(B) antagonists containing a diphenylmethylamine acetamide side chain". . p. 3679 - 3689. Retrieved 2007/10/03.