Benzo[h][1,6]naphthyridine

Base Information

• Chemical Name: Benzo[h][1,6]naphthyridine
• CAS No.: 230-51-3
• Molecular Formula: C12H8 N2
• Molecular Weight: 180.209
• DSSTox Substance ID: DTXSID00497113
• Nikkaji Number: J3.308.967H
• Wikidata: Q82346485
• Mol file: 230-51-3.mol

Synonyms:benzo[h][1,6]naphthyridine;230-51-3;SCHEMBL4164142;DTXSID00497113

Chemical Property of Benzo[h][1,6]naphthyridine

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 180.068748264
• Heavy Atom Count: 14
• Complexity: 205

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C3=C(C=CC=N3)C=N2

Technology Process of Benzo[h][1,6]naphthyridine

There total 2 articles about Benzo[h][1,6]naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(4R,5S)-5-Methyl-3-(2-pyridin-2-yl-phenyl)-4,5-dihydro-3H-[1,2,3]triazol-4-yl]-morpholine → 2-(2-pyridyl)aniline (29528-30-1) + 5-methylbenzo[h]-1,6-naphthyridine (34016-27-8) + benzo[h]-1,6-naphthyridine (230-51-3) + 5-Ethyl-benzo[h][1,6]naphthyridine

Guidance literature:

With iodine; In benzene; Irradiation;

Reference yield:

4-[(4S,5R)-5-Ethyl-3-(2-pyridin-2-yl-phenyl)-4,5-dihydro-3H-[1,2,3]triazol-4-yl]-morpholine → 2-(2-pyridyl)aniline (29528-30-1) + benzo[h]-1,6-naphthyridine (230-51-3) + 5-Ethyl-benzo[h][1,6]naphthyridine + 5-Propyl-benzo[h][1,6]naphthyridine

Guidance literature:

With iodine; In benzene; Title compound not separated from byproducts; Irradiation;

Reference yield: 92.0%

α-bromoacetophenone (70-11-1) + benzo[h]-1,6-naphthyridine (230-51-3) → 6-phenacyl-1,6-benzonaphthyridinium bromide (87056-45-9)

Guidance literature:

In tetrahydrofuran; for 96h;

Downstream raw materials:

6-benzyl-1,6-benzo(h)naphthydrine chloride

6-phenacyl-1,6-benzonaphthyridinium bromide

6-(2,4-dinitrophenyl)-1,6-benzo(h)naphthydrine chloride

Refernces