(Tetrahydrofuran-3-yl)methanol

Base Information

• Chemical Name: (Tetrahydrofuran-3-yl)methanol
• CAS No.: 15833-61-1
• Molecular Formula: C₅H₁₀O₂
• Molecular Weight: 102.133
• Hs Code.: 29321900
• European Community (EC) Number: 629-195-6
• DSSTox Substance ID: DTXSID40935903
• Nikkaji Number: J146.586D
• ChEMBL ID: CHEMBL2287525
• Mol file: 15833-61-1.mol

Synonyms:15833-61-1;(tetrahydrofuran-3-yl)methanol;Tetrahydro-3-furanmethanol;oxolan-3-ylmethanol;Tetrahydro-3-furanylmethanol;tetrahydrofuran-3-ylmethanol;3-(hydroxymethyl)tetrahydrofuran;tetrahydrofuran-3-methanol;3-FURANMETHANOL, TETRAHYDRO-;(oxolan-3-yl)methanol;(Tetrahydro-furan-3-yl)-methanol;.+/-.-Tetrahydro-3-furanmethanol;3-HYDROXYMETHYLTETRAHYDROFURAN;MFCD00075198;(+-)-Tetrahydro-3-furanmethanol;(3-oxolanyl)methan-1-ol;tetrahydro-3-furan-methanol;tetrahydrofuran-3-yl methanol;Tetrahydrofuran-3-yl-methanol;SCHEMBL101449;(tetrahydro-3-furanyl)methanol;Tetrahydro-3-furanylmethanol #;tetrahydro-furan-3-yl-methanol;(tetrahydrofuran-3-yl)-methanol;CHEMBL2287525;rac-tetrahydrofuran-3-ylmethanol;(RS)-tetrahydrofuran-3-methanol;DTXSID40935903;(+/-)-tetrahydro-3-furanmethanol;CS-D1159;AKOS000249169;AKOS016842504;PB30186;PB30586;PB34870;BP-12652;DS-13940;SY030918;A3483;AM20080421;FT-0660726;FT-0684785;FT-0684786;EN300-41399;J-009491;J-502296;J-502552;J-524870;F0001-0565;Z335245192;(Tetrahydrofuran-3-yl)methanol;Tetrahydro-3-furanmethanol, contains 250 ppm BHT as inhibitor, 99%

Chemical Property of (Tetrahydrofuran-3-yl)methanol

Chemical Property:

• Vapor Pressure: 0.0899mmHg at 25°C
• Refractive Index: n20/D 1.456(lit.)
• Boiling Point: 198.6 °C at 760 mmHg
• PKA: 14.81±0.10(Predicted)
• Flash Point: 97.8 °C
• PSA: 29.46000
• Density: 1.038 g/cm³
• LogP: 0.01520
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 102.068079557
• Heavy Atom Count: 7
• Complexity: 54

Purity/Quality:

98% ^*data from raw suppliers

Tetrahydro-3-furanmethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1COCC1CO

Technology Process of (Tetrahydrofuran-3-yl)methanol

There total 20 articles about (Tetrahydrofuran-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.7%

tetrahydrofuran-3-carboxaldehyde (79710-86-4) → 3-tetrahydrofuranmethanol (124391-75-9,124506-31-6,15833-61-1)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethanol; at 20 ℃; for 2h; under 48754.9 Torr; Solvent; Pressure; Autoclave; Large scale;

Reference yield: 95.5%

3-hydroxymethyl-2,5-dihydrofuran → 3-tetrahydrofuranmethanol (124391-75-9,124506-31-6,15833-61-1)

Guidance literature:

With palladium on activated charcoal; hydrogen; In isopropyl alcohol; at 50 ℃; for 5h; under 3750.38 Torr; Pressure; Solvent; Reagent/catalyst; Autoclave; Large scale;

Reference yield: 90.0%

α-hydroxymethyl-γ-butyrolactone (18132-98-4) → 3-tetrahydrofuranmethanol (124391-75-9,124506-31-6,15833-61-1)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at 60 ℃; for 8h; Temperature;

upstream raw materials:

3-tetrahydrofuroic acid

2-(allyloxy)ethyl bromide

3-(2-iodoethoxy)prop-1-ene

9-hydroxymethyl-7,12-dioxaspiro<5,6>dodecane

Downstream raw materials:

3-tetrahydrofuroic acid

(tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate

3-methyltetrahydrofuran

dihydro-4-methyl-2(3H)-furanone

Refernces

• 1、 Song, Song,Wang, Dong,Di, Lu,Wang, Chuanming,Dai, Weili,Wu, Guangjun,Guan, Naijia,Li, Landong. "Robust cobalt oxide catalysts for controllable hydrogenation of carboxylic acids to alcohols". . p. 250 - 257. Retrieved 2018/02/20.
• 2、 -. "Production technology for 3-hydroxymethyltetrahydrofuran". Paragraph 0033; 0034; 0037; 0043. . Retrieved 2018/10/19.