2,4-dimethoxy-1-(prop-1-en-2-yl)benzene

Base Information

• Chemical Name: 2,4-dimethoxy-1-(prop-1-en-2-yl)benzene
• CAS No.: 17736-45-7
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.231
• Mol file: 17736-45-7.mol

Synonyms:2,4-dimethoxy-1-(prop-1-en-2-yl)benzene

Chemical Property of 2,4-dimethoxy-1-(prop-1-en-2-yl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-dimethoxy-1-(prop-1-en-2-yl)benzene

There total 6 articles about 2,4-dimethoxy-1-(prop-1-en-2-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2,4-dimethoxybenzophenone (3555-84-8) + methyl-triphenylphosphonium iodide (2065-66-9) → 2,4-dimethoxy-1-(prop-1-en-2-yl)benzene (17736-45-7)

Guidance literature:

2,4-dimethoxybenzophenone; methyl-triphenylphosphonium iodide; In tetrahydrofuran; for 0.25h; Inert atmosphere;

With potassium tert-butylate; In tetrahydrofuran; at 40 ℃; for 1.41667h; Inert atmosphere;

DOI:10.1021/ol400432x

Reference yield: 78.0%

Methyltriphenylphosphonium bromide (1779-49-3) + 2',4'-dimethoxyacetophenone (829-20-9) → 2,4-dimethoxy-1-(prop-1-en-2-yl)benzene (17736-45-7)

Guidance literature:

Methyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 2h; Inert atmosphere;

2',4'-dimethoxyacetophenone; In tetrahydrofuran; hexane; at 20 ℃; Inert atmosphere;

DOI:10.1002/adsc.201900749

Reference yield: 70.0%

methyl magnesium iodide (917-64-6) + 2',4'-dimethoxyacetophenone (829-20-9) → 2,4-dimethoxy-1-(prop-1-en-2-yl)benzene (17736-45-7)

Guidance literature:

methyl magnesium iodide; 2',4'-dimethoxyacetophenone; In diethyl ether; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In diethyl ether; water; at 20 ℃;

DOI:10.1007/s11172-020-3013-2

upstream raw materials:

methyl magnesium iodide

2',4'-dimethoxyacetophenone

Methyltriphenylphosphonium bromide

2,4-dimethoxybenzophenone

Downstream raw materials:

2,4-dihydroxy-1-isopropylbenzene

1-isopropyl-2,4-dimethyloxybenzene

1-ethynyl-5-isopropyl-2,4-dimethoxybenzene

((5-isopropyl-2,4-dimethoxyphenyl)ethynyl)trimethylsilane

Refernces

• 1、 Ohmura, Toshimichi,Kusaka, Satoshi,Torigoe, Takeru,Suginome, Michinori. "Iridium-Catalyzed C(sp3)?H Addition of Methyl Ethers across Intramolecular Carbon–Carbon Double Bonds Giving 2,3-Dihydrobenzofurans". supporting information. p. 4448 - 4453. Retrieved 2019/09/16.
• 2、 Shen, Jianchen,Xu, Biping,Zhang, Min,Su, Weiping. "Branched-Selective Decarboxylative Heck Reaction with Electronically Unbiased Olefins". supporting information. p. 2768 - 2773. Retrieved 2018/05/30.