Technology Process of ((5-isopropyl-2,4-dimethoxyphenyl)ethynyl)trimethylsilane
There total 5 articles about ((5-isopropyl-2,4-dimethoxyphenyl)ethynyl)trimethylsilane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper(l) iodide; triethylamine;
bis-triphenylphosphine-palladium(II) chloride;
Heating / reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: palladium 10% on activated carbon; hydrogen / ethanol / 17 h / 20 °C / Inert atmosphere
2.1: tetra-N-butylammonium tribromide / chloroform / 2 h / 20 °C / Inert atmosphere
3.1: n-butyllithium / diethyl ether; tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere
3.2: 1 h / -78 °C / Inert atmosphere
4.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / toluene / 17 h / 20 - 45 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; palladium 10% on activated carbon; hydrogen; tetra-N-butylammonium tribromide; triethylamine;
In
tetrahydrofuran; diethyl ether; ethanol; chloroform; toluene;
DOI:10.1016/j.bmcl.2019.126809
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetra-N-butylammonium tribromide / chloroform / 2 h / 20 °C / Inert atmosphere
2.1: n-butyllithium / diethyl ether; tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere
2.2: 1 h / -78 °C / Inert atmosphere
3.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / toluene / 17 h / 20 - 45 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; tetra-N-butylammonium tribromide; triethylamine;
In
tetrahydrofuran; diethyl ether; chloroform; toluene;
DOI:10.1016/j.bmcl.2019.126809